Open-vessel Synthesis of Poly-N-methoxyethylglycine
Abstract Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic stability. One type of polypeptoids, poly-N-methoxyethylglycine (P-Nmeg), has been found to possess remarkable hydrophilicity and notable properties in terms of protein, cell, and bacterial antifouling. However, the currently known synthesis methods of P-Nmeg include solid-phase synthesis, which is time-consuming and difficult to scale up, and N-substituted N-carboxyanhydride (NNCA) ring-opening polymerization, whose monomers were difficult to store. In this study, we used the chemical stable Nmeg N-phenoxycarbonyl (NPC) as the monomer, which was obtained without the use of highly toxic reactants, such as phosgene or phosphorus halide, to synthesize P-Nmeg under open-vessel conditions. By adding $ BnNH_{2} $ as an initiator at 80 °C, we can obtain controllable short chain length P-Nmeg with narrow dispersity..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Chemical Research in Chinese Universities - 40(2024), 1 vom: 12. Jan., Seite 153-158 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Guojian [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
-methoxyethylglycine |
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| Anmerkungen: |
© Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2024 |
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| doi: |
10.1007/s40242-024-3260-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR054549140 |
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| 520 | |a Abstract Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic stability. One type of polypeptoids, poly-N-methoxyethylglycine (P-Nmeg), has been found to possess remarkable hydrophilicity and notable properties in terms of protein, cell, and bacterial antifouling. However, the currently known synthesis methods of P-Nmeg include solid-phase synthesis, which is time-consuming and difficult to scale up, and N-substituted N-carboxyanhydride (NNCA) ring-opening polymerization, whose monomers were difficult to store. In this study, we used the chemical stable Nmeg N-phenoxycarbonyl (NPC) as the monomer, which was obtained without the use of highly toxic reactants, such as phosgene or phosphorus halide, to synthesize P-Nmeg under open-vessel conditions. By adding $ BnNH_{2} $ as an initiator at 80 °C, we can obtain controllable short chain length P-Nmeg with narrow dispersity. | ||
| 650 | 4 | |a Open-vessel |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Polypeptoid synthesis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Poly- |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a -methoxyethylglycine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Stable monomer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Narrow dispersity |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ma, Ke |4 aut | |
| 700 | 1 | |a Chen, Qi |4 aut | |
| 700 | 1 | |a Zhang, Donghui |4 aut | |
| 700 | 1 | |a Liu, Runhui |4 aut | |
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