Synthesis, characterization and evaluation of the simple benzaldoximes protective effect against lipid peroxidation
A series of fourteen benzaldoximes were synthetized and evaluated for antioxidant activity using lipid peroxidation (LP) method based on TBA-MDA assay, selecting BHA, BHT, troxol and quercetin as positive controls. Except for compounds 5, 6 and 9, most of the tested compounds had antioxidant properties. Compounds 12 ($ IC_{50} $ = 25.7 ± 5.2 μM) and 13 ($ IC_{50} $ = 55.3 ± 21.1 μM) expressed excellent antioxidant activity, having results comparable to Trolox ($ IC_{50} $ = 22.0 ± 6.0 μM) and quercetin ($ IC_{50} $ = 23.0 ± 6.0 μM). The results of our study on benzaldoximes might constitute a sort of a promising starting point for the development of new LP inhibitors useful for the prevention of oxidative damage. Graphical Abstract.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
|---|---|
| Enthalten in: |
Chemical papers - 78(2023), 1 vom: 28. Sept., Seite 331-341 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lazarević, Jelena [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Antioxidant activity |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s11696-023-03090-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR054506778 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR054506778 | ||
| 003 | DE-627 | ||
| 005 | 20240125064755.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240125s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11696-023-03090-x |2 doi | |
| 035 | |a (DE-627)SPR054506778 | ||
| 035 | |a (SPR)s11696-023-03090-x-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lazarević, Jelena |e verfasserin |0 (orcid)0000-0001-7716-9160 |4 aut | |
| 245 | 1 | 0 | |a Synthesis, characterization and evaluation of the simple benzaldoximes protective effect against lipid peroxidation |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a A series of fourteen benzaldoximes were synthetized and evaluated for antioxidant activity using lipid peroxidation (LP) method based on TBA-MDA assay, selecting BHA, BHT, troxol and quercetin as positive controls. Except for compounds 5, 6 and 9, most of the tested compounds had antioxidant properties. Compounds 12 ($ IC_{50} $ = 25.7 ± 5.2 μM) and 13 ($ IC_{50} $ = 55.3 ± 21.1 μM) expressed excellent antioxidant activity, having results comparable to Trolox ($ IC_{50} $ = 22.0 ± 6.0 μM) and quercetin ($ IC_{50} $ = 23.0 ± 6.0 μM). The results of our study on benzaldoximes might constitute a sort of a promising starting point for the development of new LP inhibitors useful for the prevention of oxidative damage. Graphical Abstract | ||
| 650 | 4 | |a Benzaldoximes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Synthesis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Antioxidant activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lipid peroxidation inhibition |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ilić, Katarina |4 aut | |
| 700 | 1 | |a Zvezdanović, Jelena |4 aut | |
| 700 | 1 | |a Stojanović, Gordana |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemical papers |d Wien : Springer Vienna, 1947 |g 78(2023), 1 vom: 28. Sept., Seite 331-341 |w (DE-627)SPR021863229 |w (DE-600)2252770-9 |x 1336-9075 |7 nnns |
| 773 | 1 | 8 | |g volume:78 |g year:2023 |g number:1 |g day:28 |g month:09 |g pages:331-341 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s11696-023-03090-x |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 78 |j 2023 |e 1 |b 28 |c 09 |h 331-341 | ||