Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation
Abstract In the pursuit of discovering new active metabolites from helicosporous hyphomycetes, rice fermentation products of Neohelicosporium griseum were examined. Eight compounds were isolated from this saprophytic fungus, namely vertixanthone (1), diaportheone A (2), 1,3,6,8-tetrahydroxyanthraquinone (3), lecanoric acid (4), decarboxycitrinone (5), 6,8-dihydroxy-4-hydroxymethyl-3,5-dimethyl-isochromen-1-one (6), decarboxyhydroxycitrinone (7), and ergosterin (8). The 1D and 2D NMR characteristics of compound 1 in DMSO-d6 were detailed for the first time. Antimicrobial testing indicated that compounds 1–4 exhibited moderate activity against Pseudomonas aeruginosa, with compound 3 also showing weak activity against Staphylococcus aureus. In-vitro cytotoxicity assays revealed that compounds 1, 3, and 4 displayed cytotoxic activity against HELA cell lines, with respective $ IC_{50} $ values of 30.8, 13.7, and 14.1 µM. Compounds 1, 3, and 4 also showed significant cytotoxicity against A549 cell lines, with respective $ IC_{50} $ values of 24.7, 7.4, and 10.3 µM..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Medicinal chemistry research - 33(2024), 2 vom: 04. Jan., Seite 308-313 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Lijuan [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Helicosporous hyphomycetes |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s00044-023-03172-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract In the pursuit of discovering new active metabolites from helicosporous hyphomycetes, rice fermentation products of Neohelicosporium griseum were examined. Eight compounds were isolated from this saprophytic fungus, namely vertixanthone (1), diaportheone A (2), 1,3,6,8-tetrahydroxyanthraquinone (3), lecanoric acid (4), decarboxycitrinone (5), 6,8-dihydroxy-4-hydroxymethyl-3,5-dimethyl-isochromen-1-one (6), decarboxyhydroxycitrinone (7), and ergosterin (8). The 1D and 2D NMR characteristics of compound 1 in DMSO-d6 were detailed for the first time. Antimicrobial testing indicated that compounds 1–4 exhibited moderate activity against Pseudomonas aeruginosa, with compound 3 also showing weak activity against Staphylococcus aureus. In-vitro cytotoxicity assays revealed that compounds 1, 3, and 4 displayed cytotoxic activity against HELA cell lines, with respective $ IC_{50} $ values of 30.8, 13.7, and 14.1 µM. Compounds 1, 3, and 4 also showed significant cytotoxicity against A549 cell lines, with respective $ IC_{50} $ values of 24.7, 7.4, and 10.3 µM. | ||
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| 700 | 1 | |a Zheng, Dege |4 aut | |
| 700 | 1 | |a Mapook, Ausana |4 aut | |
| 700 | 1 | |a Lu, Yongzhong |4 aut | |
| 700 | 1 | |a Jayawardena, Ruvishika S. |4 aut | |
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