Vitamin D profile in autism spectrum disorder children and its relation to the disease severity
Background The study aimed to investigate whether vitamin D deficiency is a common finding in autism spectrum disorder (ASD) children and whether such deficiency is related to ASD severity and language age or not. Methods A cross-sectional observational study was conducted on ASD children aged 2-6 years. The participants were 80 Egyptian children with ASD. All participants were assessed using DSM-V, the Childhood Autism Rating Scale (CARS), language assessment, and assessment of serum vitamin D using ADVIA Centaur Vit D assay. Results About 63.8% of ASD children have vitamin D insufficiency, 28.8 % have vitamin D deficiency, and 7.4% have normal serum levels. No correlation was found between serum vitamin D and language age (r = -0.085, P = 0.451), DSM 5 severity levels (r = 0.$ 015^{,} $P= 0.894), and CARS scores (r= 0.075, P= 0.511). Conclusion ASD children have lower serum vitamin D levels, which may be one of the environmental factors contributing to ASD development in genetically susceptible individuals, and its correction may be helpful as adjuvant therapy for ASD..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
The Egyptian journal of otolaryngology - 40(2024), 1 vom: 18. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mansour, Amira [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
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| Anmerkungen: |
© The Author(s) 2024 |
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| doi: |
10.1186/s43163-024-00573-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR054442915 |
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| 520 | |a Background The study aimed to investigate whether vitamin D deficiency is a common finding in autism spectrum disorder (ASD) children and whether such deficiency is related to ASD severity and language age or not. Methods A cross-sectional observational study was conducted on ASD children aged 2-6 years. The participants were 80 Egyptian children with ASD. All participants were assessed using DSM-V, the Childhood Autism Rating Scale (CARS), language assessment, and assessment of serum vitamin D using ADVIA Centaur Vit D assay. Results About 63.8% of ASD children have vitamin D insufficiency, 28.8 % have vitamin D deficiency, and 7.4% have normal serum levels. No correlation was found between serum vitamin D and language age (r = -0.085, P = 0.451), DSM 5 severity levels (r = 0.$ 015^{,} $P= 0.894), and CARS scores (r= 0.075, P= 0.511). Conclusion ASD children have lower serum vitamin D levels, which may be one of the environmental factors contributing to ASD development in genetically susceptible individuals, and its correction may be helpful as adjuvant therapy for ASD. | ||
| 650 | 4 | |a Vitamin D |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Autism spectrum disorder |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Zaki, Maysaa |0 (orcid)0000-0001-5431-0248 |4 aut | |
| 700 | 1 | |a Abou-Elsaad, Tamer |0 (orcid)0000-0002-8591-966X |4 aut | |
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