Anti-Inflammatory, Wound Healing, and Hepatoprotective Effects of Ethanol Extract of Rice Bran in Rodent Models
Rice bran is an essential co-product in rice meals with many biological activities. This study was aimed at evaluating the anti-inflammatory, wound healing, and hepatoprotective effects of ethanol extract of rice bran in vivo. The anti-inflammatory and hepatoprotective studies were performed in rats, and the wound-healing study was conducted in mice. Carrageenan and carbon tetrachloride were used to induce inflammation and hepatotoxicity respectively. The wound-healing activity of rice bran extract (RBE) was tested by creating a circular wound using a biopsy punch. For all the studies, animals were treated with RBE at a dose rate of 100 mg/kg and 200 mg/kg body weight (bwt). It was observed that RBE dose-dependently reduced the carrageenan-induced paw edema and wound-closing time (9–10 days) compared with that of control rats (12 days). Histological examination of the inflamed rat paw tissue showed massive infiltration of inflammatory cells, which was significantly reduced by RBE treatment. Intra-peritoneal injection of $ CCl_{4} $ increased the serum AST and ALT levels, which were significantly (p < 0.05) decreased by RBE treatment in a dose-dependent manner. The histological section of the liver tissue showed severe hepatic cell damage in $ CCl_{4} $-injected animals, which were distinctly regenerated by RBE treatment (200 mg/kg bwt). These results demonstrated that RBE has potent anti-inflammatory, wound-healing, and hepatoprotective effects in the experimental animal..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Pharmaceutical chemistry journal - 57(2023), 9 vom: Dez., Seite 1410-1417 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Saha, Pritam [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
ALT |
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| Anmerkungen: |
© Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s11094-023-03004-x |
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| funding: |
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| 520 | |a Rice bran is an essential co-product in rice meals with many biological activities. This study was aimed at evaluating the anti-inflammatory, wound healing, and hepatoprotective effects of ethanol extract of rice bran in vivo. The anti-inflammatory and hepatoprotective studies were performed in rats, and the wound-healing study was conducted in mice. Carrageenan and carbon tetrachloride were used to induce inflammation and hepatotoxicity respectively. The wound-healing activity of rice bran extract (RBE) was tested by creating a circular wound using a biopsy punch. For all the studies, animals were treated with RBE at a dose rate of 100 mg/kg and 200 mg/kg body weight (bwt). It was observed that RBE dose-dependently reduced the carrageenan-induced paw edema and wound-closing time (9–10 days) compared with that of control rats (12 days). Histological examination of the inflamed rat paw tissue showed massive infiltration of inflammatory cells, which was significantly reduced by RBE treatment. Intra-peritoneal injection of $ CCl_{4} $ increased the serum AST and ALT levels, which were significantly (p < 0.05) decreased by RBE treatment in a dose-dependent manner. The histological section of the liver tissue showed severe hepatic cell damage in $ CCl_{4} $-injected animals, which were distinctly regenerated by RBE treatment (200 mg/kg bwt). These results demonstrated that RBE has potent anti-inflammatory, wound-healing, and hepatoprotective effects in the experimental animal. | ||
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