Green pathway for the construction of aryl-1,8-naphthyridine-thiazole scaffolds and in vitro-antimicrobial evaluation, DNA binding interactions, viscosity measurements, molecular modeling studies and ADME properties
Ecofriendly approachable research can bring cost-effective technology; it is essential and desirable in the current state-of-the-art research. Green synthesis of substituted aryl-1,8-naphthyridine-thiazole-4-carboxamide derivatives and evaluation of their antibacterial and antifungal activity of all the synthesized compounds demonstrated remarkable in vitro microbial activity as well as DNA binding studies, and viscosity measurements by electronic absorption spectroscopy. The intrinsic binding constants (Kb) values of (5a–f) molecules with Ct-DNA obtained from UV–Vis spectroscopy. Molecular docking studies results and ADME properties were well complemented to the DNA binding intercalative studies. Graphical abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
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| Enthalten in: |
Research on chemical intermediates - 50(2023), 1 vom: 07. Dez., Seite 265-279 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sonyanaik, Banoth [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Aryl-1,8-naphthyridines |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s11164-023-05176-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Ecofriendly approachable research can bring cost-effective technology; it is essential and desirable in the current state-of-the-art research. Green synthesis of substituted aryl-1,8-naphthyridine-thiazole-4-carboxamide derivatives and evaluation of their antibacterial and antifungal activity of all the synthesized compounds demonstrated remarkable in vitro microbial activity as well as DNA binding studies, and viscosity measurements by electronic absorption spectroscopy. The intrinsic binding constants (Kb) values of (5a–f) molecules with Ct-DNA obtained from UV–Vis spectroscopy. Molecular docking studies results and ADME properties were well complemented to the DNA binding intercalative studies. Graphical abstract | ||
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