Exposure to polycyclic aromatic hydrocarbons increases the risk of poor sleep pattern in US adults: results from the NHANES (2005–2010)
Abstract Recently, polycyclic aromatic hydrocarbons (PAHs) were found to be linked to various diseases. The current study’s objective was to explore whether or not there was a relation between PAH exposure and poor sleep pattern. We evaluated nine urine PAH metabolites as exposures in our cross-sectional research based on the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Logistic regression, restricted cubic spline regression (RCS) model, weighted quantile sum (WQS) regression, subgroup analysis, and mediation analysis were used to assess the associations between PAH metabolism and poor sleep pattern risk. After controlling for all confounding variables, several primary PAH metabolites, namely 1-hydroxynapthalene (1-NAP, OR 1.32, 95% CI 1.04–1.68), 2-hydroxyfluorene (2-FLU, OR 1.34, 95% CI 1.05–1.71), 1-hydroxyphenanthrene (1-PHE, OR 1.30, 95% CI 1.03–1.64), 9-hydroxyfluorene (9-FLU, OR 1.38, 95% CI 1.09–1.74), and ∑PAHs (OR 1.33, 95% CI 1.05–1.69), compared to the bottom tertile, were associated with increased risk of poor sleep pattern. The WQS regression analysis showed that 9-FLU and 1-NAP comprised the two most important factors related to poor sleep pattern. Mediation analysis revealed that inflammation acted as a mediator between PAHs and the prevalence of poor sleep pattern. In conclusion, exposure to PAHs may be associated with poor sleep pattern. Inflammation is a mediator of the effects of PAH exposure on poor sleep pattern..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Environmental science and pollution research - 30(2023), 53 vom: 20. Okt., Seite 114406-114419 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Qian [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Inflammation |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s11356-023-30419-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Recently, polycyclic aromatic hydrocarbons (PAHs) were found to be linked to various diseases. The current study’s objective was to explore whether or not there was a relation between PAH exposure and poor sleep pattern. We evaluated nine urine PAH metabolites as exposures in our cross-sectional research based on the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Logistic regression, restricted cubic spline regression (RCS) model, weighted quantile sum (WQS) regression, subgroup analysis, and mediation analysis were used to assess the associations between PAH metabolism and poor sleep pattern risk. After controlling for all confounding variables, several primary PAH metabolites, namely 1-hydroxynapthalene (1-NAP, OR 1.32, 95% CI 1.04–1.68), 2-hydroxyfluorene (2-FLU, OR 1.34, 95% CI 1.05–1.71), 1-hydroxyphenanthrene (1-PHE, OR 1.30, 95% CI 1.03–1.64), 9-hydroxyfluorene (9-FLU, OR 1.38, 95% CI 1.09–1.74), and ∑PAHs (OR 1.33, 95% CI 1.05–1.69), compared to the bottom tertile, were associated with increased risk of poor sleep pattern. The WQS regression analysis showed that 9-FLU and 1-NAP comprised the two most important factors related to poor sleep pattern. Mediation analysis revealed that inflammation acted as a mediator between PAHs and the prevalence of poor sleep pattern. In conclusion, exposure to PAHs may be associated with poor sleep pattern. Inflammation is a mediator of the effects of PAH exposure on poor sleep pattern. | ||
| 650 | 4 | |a Polycyclic aromatic hydrocarbons |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Poor sleep pattern |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Trouble sleeping |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Short sleep duration |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a NHANES |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Peng, Kun |4 aut | |
| 700 | 1 | |a Xin, Li-Hong |4 aut | |
| 700 | 1 | |a Zhao, Jie |4 aut | |
| 700 | 1 | |a Li, Yu-Jie |4 aut | |
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