Mitigation of Tribocharging in Pharmaceutical Powders using Surface Modified V-Blenders
Introduction The pharmaceutical industry involves handling of powders on a large scale for manufacturing of solid dosage forms such as tablets and capsules constituting about 85% of the dosage forms. During this manufacturing process, powders get electrostatically charged due to numerous particle–particle and particle-equipment wall collisions. Most of the pharmaceutical powders are insulators in nature and they accumulate charge for longer durations making it difficult to dissipate the generated charge. In this study, a surface modified blender has been used to analyze tribocharging in pharmaceutical powders. Methods The surface modified blender has been fabricated using two types of materials, an insulator, and a conductor. The conductor or the metal arm induces charge of opposite polarity to that of the charge induced by the insulator arm and the overall charge on the powder decreases during the tumbling motion of the blender. Ibuprofen was used as the model drug and processed in aluminum, polyvinyl chloride (PVC), stainless steel, surface modified aluminum-PVC (Al-PVC) and surface modified stainless steel- PVC (SS-PVC) blender at 20% RH for different blending times such as 2, 10, 20, 30 and 40 min. To better understand the tribocharging phenomenon in surface modified V blenders, an experimentally validated computational model was developed using Discrete Element Method (DEM) modeling. Results Significant reduction (> 50%) in electrostatic charge was observed for Ibuprofen using surface modified blenders in comparison to metal only and insulator only V blenders. Additionally, an identical charging trend was observed between the simulation and experimental data. Conclusion It was established that careful selection of equipment materials could significantly reduce the electrostatic charging of pharmaceutical powders and DEM model could be a really useful tool in assessing the applicability of the modified V blenders..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
|---|---|
| Enthalten in: |
Pharmaceutical research - 40(2023), 10 vom: Okt., Seite 2371-2381 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Mehta, Tanu [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Discrete element method |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s11095-023-03612-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR05379723X |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR05379723X | ||
| 003 | DE-627 | ||
| 005 | 20231121064810.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231121s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11095-023-03612-y |2 doi | |
| 035 | |a (DE-627)SPR05379723X | ||
| 035 | |a (SPR)s11095-023-03612-y-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Mehta, Tanu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Mitigation of Tribocharging in Pharmaceutical Powders using Surface Modified V-Blenders |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Introduction The pharmaceutical industry involves handling of powders on a large scale for manufacturing of solid dosage forms such as tablets and capsules constituting about 85% of the dosage forms. During this manufacturing process, powders get electrostatically charged due to numerous particle–particle and particle-equipment wall collisions. Most of the pharmaceutical powders are insulators in nature and they accumulate charge for longer durations making it difficult to dissipate the generated charge. In this study, a surface modified blender has been used to analyze tribocharging in pharmaceutical powders. Methods The surface modified blender has been fabricated using two types of materials, an insulator, and a conductor. The conductor or the metal arm induces charge of opposite polarity to that of the charge induced by the insulator arm and the overall charge on the powder decreases during the tumbling motion of the blender. Ibuprofen was used as the model drug and processed in aluminum, polyvinyl chloride (PVC), stainless steel, surface modified aluminum-PVC (Al-PVC) and surface modified stainless steel- PVC (SS-PVC) blender at 20% RH for different blending times such as 2, 10, 20, 30 and 40 min. To better understand the tribocharging phenomenon in surface modified V blenders, an experimentally validated computational model was developed using Discrete Element Method (DEM) modeling. Results Significant reduction (> 50%) in electrostatic charge was observed for Ibuprofen using surface modified blenders in comparison to metal only and insulator only V blenders. Additionally, an identical charging trend was observed between the simulation and experimental data. Conclusion It was established that careful selection of equipment materials could significantly reduce the electrostatic charging of pharmaceutical powders and DEM model could be a really useful tool in assessing the applicability of the modified V blenders. | ||
| 650 | 4 | |a discrete element method |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a surface modified V blender |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a tribocharging |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Mukherjee, Raj |4 aut | |
| 700 | 1 | |a Shah, Ami |4 aut | |
| 700 | 1 | |a Mastriani, Trey |4 aut | |
| 700 | 1 | |a Duran, Tibo |4 aut | |
| 700 | 1 | |a Chaudhuri, Bodhisattwa |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pharmaceutical research |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1984 |g 40(2023), 10 vom: Okt., Seite 2371-2381 |w (DE-627)SPR016546105 |w (DE-600)2036232-8 |x 1573-904X |7 nnns |
| 773 | 1 | 8 | |g volume:40 |g year:2023 |g number:10 |g month:10 |g pages:2371-2381 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s11095-023-03612-y |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 40 |j 2023 |e 10 |c 10 |h 2371-2381 | ||