Improves immunological and histological alterations associated with Polycystic ovarian syndrome in DHEA -induced mice by Licorice extract
Abstract Polycystic ovary syndrome (PCOS) is a complex syndrome that causes infertility in women. Licorice is one of the medicinal plants with antioxidant properties used to treat diseases. This study investigated the anti-inflammatory effect of licorice extract on PCOS. After induction of PCOS by subcutaneous injection (SC) of dehydroepiandrosterone (DHEA) (60 mg/kg) in BALB/C mice for 21 days, the mice were treated with licorice extract (50 mg/kg) for 21 days. At the end of experimental procedures, ovarian morphology, blood antioxidant capacity, nitric oxide (NO), the abundance of Treg cells, and expression of matrix metalloproteinase-9 (MMP-9), transforming growth factor-ß (TGF-ß), cyclooxygenase-2 genes (COX-2), and tumor necrosis factor-alpha (TNF-α) were measured. The estrus cycle returned to normal after treatment with licorice extract. It was observed that the licorice number of ovarian cysts was significantly higher in the licorice group than in the PCOS group, and the corpus luteum was lower than in the control group. NO, FRAP, and Treg cell numbers did not significantly alter. The TGF- gene’s expression level significantly increased, but the expression level of TNF-α, COX-2, and MMP-9 did not change significantly. Immune responses play an important role in the development of inflammation. Licorice extract, with anti-inflammatory properties, may be an effective supplement in improving the histological and immunological changes of PCOS..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Comparative haematology international - 32(2023), 5 vom: 26. Juli, Seite 827-835 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amirhoseiny, Ensieh Seif [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Inflammatory markers |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s00580-023-03492-z |
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| 520 | |a Abstract Polycystic ovary syndrome (PCOS) is a complex syndrome that causes infertility in women. Licorice is one of the medicinal plants with antioxidant properties used to treat diseases. This study investigated the anti-inflammatory effect of licorice extract on PCOS. After induction of PCOS by subcutaneous injection (SC) of dehydroepiandrosterone (DHEA) (60 mg/kg) in BALB/C mice for 21 days, the mice were treated with licorice extract (50 mg/kg) for 21 days. At the end of experimental procedures, ovarian morphology, blood antioxidant capacity, nitric oxide (NO), the abundance of Treg cells, and expression of matrix metalloproteinase-9 (MMP-9), transforming growth factor-ß (TGF-ß), cyclooxygenase-2 genes (COX-2), and tumor necrosis factor-alpha (TNF-α) were measured. The estrus cycle returned to normal after treatment with licorice extract. It was observed that the licorice number of ovarian cysts was significantly higher in the licorice group than in the PCOS group, and the corpus luteum was lower than in the control group. NO, FRAP, and Treg cell numbers did not significantly alter. The TGF- gene’s expression level significantly increased, but the expression level of TNF-α, COX-2, and MMP-9 did not change significantly. Immune responses play an important role in the development of inflammation. Licorice extract, with anti-inflammatory properties, may be an effective supplement in improving the histological and immunological changes of PCOS. | ||
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