Strongyloides stercoralis infection: an underlying cause of invasive bacterial infections of enteric origin. Results from a prospective cross-sectional study of a northern Italian tertiary hospital
Purpose of the study We assessed the prevalence of S. stercoralis in a cohort of inpatients with invasive bacterial infections of enteric origin to investigate whether the parasite may facilitate these bacterial infections even in the absence of larval hyperproliferation. Methods We performed a prospective cross-sectional study in a hospital in northern Italy. Subjects admitted due to invasive bacterial infection of enteric origin and potential previous exposure to S. stercoralis were systematically enrolled over a period of 10 months. S. stercoralis infection was investigated with an in-house PCR on a single stool sample and with at least one serological method (in-house IFAT and/or ELISA Bordier). Univariate, bi-variate and logistic regression analyses were performed. Results Strongyloidiasis was diagnosed in 14/57 patients (24.6%; 95% confidence interval 14.1–37.8%) of which 10 were Italians (10/49, 20.4%) and 4 were migrants (4/8, 50.0%). Stool PCR was performed in 43/57 patients (75.4%) and no positive results were obtained. Strongyloidiasis was found to be significantly associated (p ≤ 0.05) with male gender, long international travels to areas at higher endemicity, deep extra-intestinal infectious localization and solid tumors. In the logistic regression model, increased risk remained for the variables deep extra-intestinal infectious localization and oncologic malignancy. Conclusions Our findings suggest a new role of chronic strongyloidiasis in favoring invasive bacterial infections of enteric origin even in the absence of evident larval dissemination outside the intestinal lumen. Further well-designed studies should be conducted to confirm our results, and possibly establish the underlying mechanisms..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Infection - 51(2023), 5 vom: 18. Juli, Seite 1541-1548 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gardini, Giulia [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Enteric sepsis |
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| Anmerkungen: |
© The Author(s) 2023 |
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| doi: |
10.1007/s15010-023-02072-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR053289145 |
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| 520 | |a Purpose of the study We assessed the prevalence of S. stercoralis in a cohort of inpatients with invasive bacterial infections of enteric origin to investigate whether the parasite may facilitate these bacterial infections even in the absence of larval hyperproliferation. Methods We performed a prospective cross-sectional study in a hospital in northern Italy. Subjects admitted due to invasive bacterial infection of enteric origin and potential previous exposure to S. stercoralis were systematically enrolled over a period of 10 months. S. stercoralis infection was investigated with an in-house PCR on a single stool sample and with at least one serological method (in-house IFAT and/or ELISA Bordier). Univariate, bi-variate and logistic regression analyses were performed. Results Strongyloidiasis was diagnosed in 14/57 patients (24.6%; 95% confidence interval 14.1–37.8%) of which 10 were Italians (10/49, 20.4%) and 4 were migrants (4/8, 50.0%). Stool PCR was performed in 43/57 patients (75.4%) and no positive results were obtained. Strongyloidiasis was found to be significantly associated (p ≤ 0.05) with male gender, long international travels to areas at higher endemicity, deep extra-intestinal infectious localization and solid tumors. In the logistic regression model, increased risk remained for the variables deep extra-intestinal infectious localization and oncologic malignancy. Conclusions Our findings suggest a new role of chronic strongyloidiasis in favoring invasive bacterial infections of enteric origin even in the absence of evident larval dissemination outside the intestinal lumen. Further well-designed studies should be conducted to confirm our results, and possibly establish the underlying mechanisms. | ||
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| 650 | 4 | |a Intestinal bacteria |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Intestinal parasitosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Intestinal helminths |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Enteric sepsis |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a De Francesco, Maria Antonia |4 aut | |
| 700 | 1 | |a Cattaneo, Chiara |4 aut | |
| 700 | 1 | |a Marchese, Valentina |4 aut | |
| 700 | 1 | |a Piccinelli, Giorgio |4 aut | |
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| 700 | 1 | |a Santagiuliana, Marzia |4 aut | |
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| 700 | 1 | |a Perandin, Francesca |4 aut | |
| 700 | 1 | |a Castelli, Francesco |4 aut | |
| 700 | 1 | |a Matteelli, Alberto |4 aut | |
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