Tyrosine-kinase inhibitor combined with iodine-125 seed brachytherapy for hepatocellular carcinoma refractory to transarterial chemoembolization: a propensity-matched study
Purpose To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients with hepatocellular carcinoma (HCC) refractory to transarterial chemoembolization (TACE). Methods Data of patients with TACE-refractory HCC who received TKI (sorafenib or lenvatinib) or TKI-I from September 2018 to December 2020 were retrospectively analyzed. A propensity score matching (PSM) was performed to diminish potential bias. The primary endpoints were overall survival (OS) and time to progression (TTP). Tumor responses and treatment-related adverse events (TRAEs) were also compared between the two groups. Results A total of 132 patients were included in this study. Under PSM, 48 paired patients were selected for comparison. The median OS was 23.2 (95% CI 20.9–25.1) months in the TKI-I group versus 13.9 (95% CI 11.1–16.7) months in the TKI group (P < 0.001). The median TTP was 12.8 (95% CI 10.1–15.5) months in the TKI-I group versus 5.8 (95% CI 5.0-6.6) months in the TKI group (P < 0.001). Patients in the TKI-I group had higher objective response rate (68.8% vs. 33.3%, P = 0.001) and disease control rate (89.6% vs. 66.7%, P = 0.007) than those in the TKI group. The incidence and severity of TRAEs in the TKI-I group were comparable to those in the TKI group (any grade, 89.7% vs. 92.2%, P = 0.620; ≥grade 3, 33.8% vs. 32.8%, P = 0.902). Conclusions TKI-I was safe and significantly improved survival over TKI alone in HCC patients with TACE refractoriness..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Cancer imaging - 23(2023), 1 vom: 25. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Guo, Yongjian [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Brachytherapy |
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| Anmerkungen: |
© The Author(s) 2023 |
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| doi: |
10.1186/s40644-023-00604-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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SPR053197267 |
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| 520 | |a Purpose To investigate the efficacy and safety of tyrosine-kinase inhibitor (TKI) combined with iodine-125 seed brachytherapy (TKI-I) versus TKI alone for patients with hepatocellular carcinoma (HCC) refractory to transarterial chemoembolization (TACE). Methods Data of patients with TACE-refractory HCC who received TKI (sorafenib or lenvatinib) or TKI-I from September 2018 to December 2020 were retrospectively analyzed. A propensity score matching (PSM) was performed to diminish potential bias. The primary endpoints were overall survival (OS) and time to progression (TTP). Tumor responses and treatment-related adverse events (TRAEs) were also compared between the two groups. Results A total of 132 patients were included in this study. Under PSM, 48 paired patients were selected for comparison. The median OS was 23.2 (95% CI 20.9–25.1) months in the TKI-I group versus 13.9 (95% CI 11.1–16.7) months in the TKI group (P < 0.001). The median TTP was 12.8 (95% CI 10.1–15.5) months in the TKI-I group versus 5.8 (95% CI 5.0-6.6) months in the TKI group (P < 0.001). Patients in the TKI-I group had higher objective response rate (68.8% vs. 33.3%, P = 0.001) and disease control rate (89.6% vs. 66.7%, P = 0.007) than those in the TKI group. The incidence and severity of TRAEs in the TKI-I group were comparable to those in the TKI group (any grade, 89.7% vs. 92.2%, P = 0.620; ≥grade 3, 33.8% vs. 32.8%, P = 0.902). Conclusions TKI-I was safe and significantly improved survival over TKI alone in HCC patients with TACE refractoriness. | ||
| 650 | 4 | |a Hepatocellular carcinoma |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Therapeutic chemoembolization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Tyrosine kinase inhibitor |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Brachytherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Combined modality therapy |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Wu, Jingqiang |4 aut | |
| 700 | 1 | |a Liang, Licong |4 aut | |
| 700 | 1 | |a Zhu, Kangshun |4 aut | |
| 700 | 1 | |a Zhou, Jingwen |4 aut | |
| 700 | 1 | |a Lin, Liteng |4 aut | |
| 700 | 1 | |a Chen, Ye |4 aut | |
| 700 | 1 | |a Cao, Bihui |4 aut | |
| 700 | 1 | |a He, Mingji |4 aut | |
| 700 | 1 | |a Lian, Hui |4 aut | |
| 700 | 1 | |a Huang, Wensou |4 aut | |
| 700 | 1 | |a Cai, Mingyue |0 (orcid)0000-0003-1155-9638 |4 aut | |
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