Easy and efficient direct conversion of aryl nitrile into aryl amide
Abstract Aryl amides and amide derivatives are important functionality in drug and drug discovery, as many drugs have it as an integral part. However, the synthesis of amide requires the condensation or coupling of amines which is a tedious or costly approach. Herein we disclosed two easy and convenient methods for directly synthesizing aryl amide using aryl nitrile in a short time with good to excellent yield via base-driven partial hydrolysis..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
Research on chemical intermediates - 49(2023), 9 vom: 12. Juli, Seite 3951-3962 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, Sumit [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Amide formation |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s11164-023-05062-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Aryl amides and amide derivatives are important functionality in drug and drug discovery, as many drugs have it as an integral part. However, the synthesis of amide requires the condensation or coupling of amines which is a tedious or costly approach. Herein we disclosed two easy and convenient methods for directly synthesizing aryl amide using aryl nitrile in a short time with good to excellent yield via base-driven partial hydrolysis. | ||
| 650 | 4 | |a Aryl nitrile |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Benzamide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Direct conversion |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Amide formation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Partial hydrolysis |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ambatwar, Ramesh |4 aut | |
| 700 | 1 | |a Khatik, Gopal L. |4 aut | |
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