Burden of influenza A (H1N1)pdm09 infection among tuberculosis patients: a prospective cohort study

Background Influenza and tuberculosis both cause significant morbidity and mortality worldwide. Therefore, this study aimed to estimate the burden of influenza A (H1N1)pdm09 virus infection among human tuberculosis patients and the general population. Methods A prospective cohort study was conducted among a cohort group (TB positive patients) as exposed and a comparison group (general population) as non-exposed. A total of 304 participants were recruited in both groups and followed for a period of 12 weeks. Of the 304 concurrently enrolled individuals, 152 were TB-positive patients (cohort group) and 152 were from the general population (comparison group).To calculate the sample size, the power of study was kept at 80% for detecting a difference at 5% alpha level assuming the 25% prevalence of respiratory viruses in cohort group compared to 12.5% in general population. An oropharyngeal swab was taken from a participant with symptoms of influenza-like illness (ILI). Samples were tested by conventional reverse transcription polymerase chain reaction (RT-PCR) for the detection of influenza A (H1N1)pdm09. All statistical analyses were conducted using R software. Results A total of 95 participants developed influenza-like illness (ILI) symptoms. Among these, 64 tested positive for influenza A(H1N1)pdm09, of which 39 were from the exposed group and 25 were from the non-exposed group. During the 12-week period of follow-up, the influenza A (H1N1)pdm09 incidence rate was 20 per 1000 people. The risk of testing positive for influenza A (H1N1)pdm09 was 1.66 times higher in the exposed group compared to the non-exposed group. The cumulative incidence indicated that 25% of the TB cohort and 16% of the comparison group were at risk of getting influenza A (H1N1)pdm09 during the 12 weeks of follow-up. Conclusion Participants from the TB cohort had a higher incidence of influenza A (H1N1)pdm09 than the general population suggesting that they should be prioritized for influenza vaccination..

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:23
Enthalten in:	BMC infectious diseases - 23(2023), 1 vom: 10. Aug.

Sprache:	Englisch

Beteiligte Personen:	Umbreen, Gulshan [VerfasserIn] Rehman, Abdul [VerfasserIn] Avais, Muhammad [VerfasserIn] Jabeen, Chanda [VerfasserIn] Sadiq, Shakera [VerfasserIn] Maqsood, Rubab [VerfasserIn] Rashid, Hamad Bin [VerfasserIn] Afzal, Saira [VerfasserIn] Chaudhry, Mamoona [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	Cohort studies Humans Incidence Influenza Prospective studies Tuberculosis Viruses

Anmerkungen:	© The Author(s) 2023

doi:	10.1186/s12879-023-08441-3

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	SPR052701034