Cardiovascular complications from steroid pulse therapy: a review
Abstract Steroid pulse therapy (SPT) is a widespread therapeutic modality used in life-threatening situations or severe diseases. However, it seems to have cardiovascular side effects. To review the cardiac complications of SPT. To search PubMed for articles on the cardiovascular complications of SPT between 1966 and August 2022 in the Scielo, Pubmed, and Embase databases. No language limitation was established. There were 36 articles: 26 case reports, and 10 small observational studies. Bradycardia, atrial fibrillation, atrial flutter, ventricular ectopic beats, and ventricular tachycardia were described during and after the infusion. The most common was bradycardia, which could be asymptomatic. Eight deaths and two cases of myocardial infarction were credited to this form of treatment. QTc prolongation was also verified with the infusion. Several arrhythmias and sudden death can occur with glucocorticoid pulse therapy. Awareness of this possibility allows the clinician to be cautious during this treatment..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
SN comprehensive clinical medicine - 5(2023), 1 vom: 03. Aug. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
de Carvalho, Jozélio Freire [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Adverse effects |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature Switzerland AG 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s42399-023-01539-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Steroid pulse therapy (SPT) is a widespread therapeutic modality used in life-threatening situations or severe diseases. However, it seems to have cardiovascular side effects. To review the cardiac complications of SPT. To search PubMed for articles on the cardiovascular complications of SPT between 1966 and August 2022 in the Scielo, Pubmed, and Embase databases. No language limitation was established. There were 36 articles: 26 case reports, and 10 small observational studies. Bradycardia, atrial fibrillation, atrial flutter, ventricular ectopic beats, and ventricular tachycardia were described during and after the infusion. The most common was bradycardia, which could be asymptomatic. Eight deaths and two cases of myocardial infarction were credited to this form of treatment. QTc prolongation was also verified with the infusion. Several arrhythmias and sudden death can occur with glucocorticoid pulse therapy. Awareness of this possibility allows the clinician to be cautious during this treatment. | ||
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