Interleukin-37 is involved in the immunopathogenesis of infectious mononucleosis
Background Multiple immunopathological responses to viruses are observed in infectious mononucleosis (IM), a manifestation of primary infection with Epstein-Barr virus (EBV). Protective effects of the negative immunoregulatory molecule interleukin-37 (IL-37) have been observed in various bacterial and viral infections. However, the function of IL-37 in IM remains unknown. Methods Flow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to determine the expression of IL-37 in the peripheral blood of patients diagnosed with IM, and the variation of lymphocyte subsets. Furthermore, the associations between IL-37 expression and the percentage of lymphocyte subgroups were analyzed. Results Patients with IM had severe immune dysfunction. The control group had a lower expression of IL-37 than the patients with IM. There were significant associations between IL-37 expression and both the proportion of $ CD3^{+} $T cells and the ratio of $ CD3^{+} %$ CD4^{+} $ to $ CD3^{+} %$ CD8^{+} $T cells. Patients with higher levels of IL-37 expression had lower levels of the liver inflammation indicators, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Conclusions IL-37 may affect the immune pathogenesis of patients with IM infected with EBV, and may have immunotherapeutic benefit for EBV-associated illnesses..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:49 |
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| Enthalten in: |
The Italian journal of pediatrics - 49(2023), 1 vom: 28. Juli |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhao, Mingsheng [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
CD3 + T cells |
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| Anmerkungen: |
© The Author(s) 2023 |
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| doi: |
10.1186/s13052-023-01498-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR052567494 |
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| 100 | 1 | |a Zhao, Mingsheng |e verfasserin |0 (orcid)0000-0001-6182-4247 |4 aut | |
| 245 | 1 | 0 | |a Interleukin-37 is involved in the immunopathogenesis of infectious mononucleosis |
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| 520 | |a Background Multiple immunopathological responses to viruses are observed in infectious mononucleosis (IM), a manifestation of primary infection with Epstein-Barr virus (EBV). Protective effects of the negative immunoregulatory molecule interleukin-37 (IL-37) have been observed in various bacterial and viral infections. However, the function of IL-37 in IM remains unknown. Methods Flow cytometry and enzyme-linked immunosorbent assay (ELISA) were used to determine the expression of IL-37 in the peripheral blood of patients diagnosed with IM, and the variation of lymphocyte subsets. Furthermore, the associations between IL-37 expression and the percentage of lymphocyte subgroups were analyzed. Results Patients with IM had severe immune dysfunction. The control group had a lower expression of IL-37 than the patients with IM. There were significant associations between IL-37 expression and both the proportion of $ CD3^{+} $T cells and the ratio of $ CD3^{+} %$ CD4^{+} $ to $ CD3^{+} %$ CD8^{+} $T cells. Patients with higher levels of IL-37 expression had lower levels of the liver inflammation indicators, alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Conclusions IL-37 may affect the immune pathogenesis of patients with IM infected with EBV, and may have immunotherapeutic benefit for EBV-associated illnesses. | ||
| 650 | 4 | |a Infectious mononucleosis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Interleukin-37 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Epstein–Barr virus |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a CD3 + T cells |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ma, Li |4 aut | |
| 700 | 1 | |a Jiang, Huihui |4 aut | |
| 700 | 1 | |a Gu, Yufeng |4 aut | |
| 700 | 1 | |a Yang, Xin |4 aut | |
| 700 | 1 | |a Liu, Riming |4 aut | |
| 700 | 1 | |a Sun, Chengming |4 aut | |
| 700 | 1 | |a Li, Yulan |4 aut | |
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| 912 | |a GBV_USEFLAG_A | ||
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