Synthesis and docking studies of pyran, pyridine and thiophene derivatives and their antitumor evaluations against cancer, hepatocellular carcinoma and cervical carcinoma cell lines
Abstract This work aimed to produce novel heterocyclic compounds such as chromene, thieno[3,2-f]chromene, chromeno[5,6-d]thiazole and quinoline derivatives. The newly synthesized heterocyclic compounds were evaluated against cancer cell lines aiming to get new anticancer agents. Dimedone underwent different multi-component reactions to produce fused thiophene, thiazole, coumarin, pyran and pyridine derivatives. Some reactions were catalyzed by effective magnetically separable nanocatalyst. The anti-proliferative activity of the newly synthesized compounds toward six cancer cell was studied. In addition, inhibitions of the most active compounds the thieno[3,2-f]chromene derivatives 16a–f toward cancer cell lines classified according to the disease were also studied. Moreover, the newly synthesized compounds were screened for their anticancer potentials against hepatocellular carcinoma HepG2 and cervical carcinoma HeLa cell lines. Anti-proliferative evaluations, inhibitions were performed for all of the synthesized compounds where the varieties of substituent through the aryl ring and the heterocyclic ring afforded compounds with high activities. Inhibitions toward cancer cell lines classified according to the disease together with inhibitions toward HepG2 and cervical carcinoma HeLa cell lines were measured. Molecular docking of compounds 15c and 18c was performed..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
Journal of the Iranian Chemical Society - 20(2023), 9 vom: 05. Juni, Seite 2163-2187 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mohareb, Rafat M. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Anti-proliferative |
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| Anmerkungen: |
© Iranian Chemical Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s13738-023-02793-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR052542521 |
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| 520 | |a Abstract This work aimed to produce novel heterocyclic compounds such as chromene, thieno[3,2-f]chromene, chromeno[5,6-d]thiazole and quinoline derivatives. The newly synthesized heterocyclic compounds were evaluated against cancer cell lines aiming to get new anticancer agents. Dimedone underwent different multi-component reactions to produce fused thiophene, thiazole, coumarin, pyran and pyridine derivatives. Some reactions were catalyzed by effective magnetically separable nanocatalyst. The anti-proliferative activity of the newly synthesized compounds toward six cancer cell was studied. In addition, inhibitions of the most active compounds the thieno[3,2-f]chromene derivatives 16a–f toward cancer cell lines classified according to the disease were also studied. Moreover, the newly synthesized compounds were screened for their anticancer potentials against hepatocellular carcinoma HepG2 and cervical carcinoma HeLa cell lines. Anti-proliferative evaluations, inhibitions were performed for all of the synthesized compounds where the varieties of substituent through the aryl ring and the heterocyclic ring afforded compounds with high activities. Inhibitions toward cancer cell lines classified according to the disease together with inhibitions toward HepG2 and cervical carcinoma HeLa cell lines were measured. Molecular docking of compounds 15c and 18c was performed. | ||
| 650 | 4 | |a Dimedone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pyran |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pyridine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Thiophene |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-proliferative |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Molecular docking |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ibrahim, Rehab A. |4 aut | |
| 700 | 1 | |a Samir, Eman M. |4 aut | |
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