Hidden in plain sight: urinary Cryptococcus neoformans missed by routine diagnostics in a patient with acute leukemia
Abstract Cryptococcuria is a rare manifestation of localized cryptococcal disease. We present a case of Cryptococcus neoformans urinary tract infection in an immunocompromised host missed by routine laboratory workup. The patient had negative blood cultures, a negative serum cryptococcal antigen (CrAg), and “non-Candida yeast” growing in urine culture that was initially dismissed as non-pathogenic. The diagnosis was ultimately made by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) from a repeat urine culture after transfer to a tertiary care center. Cryptococcus should be considered in the differential of refractory urinary tract infections growing non-Candida yeast..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Annals of clinical microbiology and antimicrobials - 21(2022), 1 vom: 12. Nov. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Weiss, Zoe F. [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Cryptoccouria |
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| Anmerkungen: |
© The Author(s) 2022 |
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| doi: |
10.1186/s12941-022-00540-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Cryptococcuria is a rare manifestation of localized cryptococcal disease. We present a case of Cryptococcus neoformans urinary tract infection in an immunocompromised host missed by routine laboratory workup. The patient had negative blood cultures, a negative serum cryptococcal antigen (CrAg), and “non-Candida yeast” growing in urine culture that was initially dismissed as non-pathogenic. The diagnosis was ultimately made by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) from a repeat urine culture after transfer to a tertiary care center. Cryptococcus should be considered in the differential of refractory urinary tract infections growing non-Candida yeast. | ||
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| 700 | 1 | |a Liakos, Alexis |4 aut | |
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| 700 | 1 | |a Cañete-Gibas, Connie |4 aut | |
| 700 | 1 | |a Wiederhold, Nathan P. |4 aut | |
| 700 | 1 | |a Basu, Sankha S. |4 aut | |
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