A new tool to screen patients with severe obstructive sleep apnea in the primary care setting: a prospective multicenter study
Background The coordination between different levels of care is essential for the management of obstructive sleep apnea (OSA). The objective of this multicenter project was to develop a screening model for OSA in the primary care setting. Methods Anthropometric data, clinical history, and symptoms of OSA were recorded in randomly selected primary care patients, who also underwent a home sleep apnea test (HSAT). Respiratory polygraphy or polysomnography were performed at the sleep unit to establish definite indication for continuous positive airway pressure (CPAP). By means of cross-validation, a logistic regression model (CPAP yes/no) was designed, and with the clinical variables included in the model, a scoring system was established using the β coefficients (PASHOS Test). In a second stage, results of HSAT were added, and the final accuracy of the model was assessed. Results 194 patients completed the study. The clinical test included the body mass index, neck circumference and observed apneas during sleep (AUC 0.824, 95% CI 0.763–0.886, P < 0.001). In a second stage, the oxygen desaturation index (ODI) of 3% (ODI3% ≥ 15%) from the HSAT was added (AUC 0.911, 95% CI 0.863–0.960, P < 0.001), with a sensitivity of 85.5% (95% CI 74.7–92.1) and specificity of 67.8% (95% CI 55.1–78.3). Conclusions The use of this model would prevent referral to the sleep unit for 55.1% of the patients. The two-stage PASHOS model is a useful and practical screening tool for OSA in primary care for detecting candidates for CPAP treatment. Clinical Trial Registration Registry: ClinicalTrials.gov; Name: PASHOS Project: Advanced Platform for Sleep Apnea Syndrome Assessment; URL: https://clinicaltrials.gov/ct2/show/NCT02591979; Identifier: NCT02591979. Date of registration: October 30, 2015..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
BMC pulmonary medicine - 22(2022), 1 vom: 15. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Peñacoba, Patricia [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Continuous positive airway pressure (CPAP) |
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| Anmerkungen: |
© The Author(s) 2022 |
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| doi: |
10.1186/s12890-022-01827-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Background The coordination between different levels of care is essential for the management of obstructive sleep apnea (OSA). The objective of this multicenter project was to develop a screening model for OSA in the primary care setting. Methods Anthropometric data, clinical history, and symptoms of OSA were recorded in randomly selected primary care patients, who also underwent a home sleep apnea test (HSAT). Respiratory polygraphy or polysomnography were performed at the sleep unit to establish definite indication for continuous positive airway pressure (CPAP). By means of cross-validation, a logistic regression model (CPAP yes/no) was designed, and with the clinical variables included in the model, a scoring system was established using the β coefficients (PASHOS Test). In a second stage, results of HSAT were added, and the final accuracy of the model was assessed. Results 194 patients completed the study. The clinical test included the body mass index, neck circumference and observed apneas during sleep (AUC 0.824, 95% CI 0.763–0.886, P < 0.001). In a second stage, the oxygen desaturation index (ODI) of 3% (ODI3% ≥ 15%) from the HSAT was added (AUC 0.911, 95% CI 0.863–0.960, P < 0.001), with a sensitivity of 85.5% (95% CI 74.7–92.1) and specificity of 67.8% (95% CI 55.1–78.3). Conclusions The use of this model would prevent referral to the sleep unit for 55.1% of the patients. The two-stage PASHOS model is a useful and practical screening tool for OSA in primary care for detecting candidates for CPAP treatment. Clinical Trial Registration Registry: ClinicalTrials.gov; Name: PASHOS Project: Advanced Platform for Sleep Apnea Syndrome Assessment; URL: https://clinicaltrials.gov/ct2/show/NCT02591979; Identifier: NCT02591979. Date of registration: October 30, 2015. | ||
| 650 | 4 | |a Obstructive sleep apnea |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Continuous positive airway pressure (CPAP) |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Llauger, Maria Antònia |4 aut | |
| 700 | 1 | |a Fortuna, Ana María |4 aut | |
| 700 | 1 | |a Flor, Xavier |4 aut | |
| 700 | 1 | |a Sampol, Gabriel |4 aut | |
| 700 | 1 | |a Pedro-Pijoan, Anna Maria |4 aut | |
| 700 | 1 | |a Grau, Núria |4 aut | |
| 700 | 1 | |a Santiveri, Carme |4 aut | |
| 700 | 1 | |a Juvanteny, Joan |4 aut | |
| 700 | 1 | |a Aoiz, José Ignacio |4 aut | |
| 700 | 1 | |a Bayó, Joan |4 aut | |
| 700 | 1 | |a Lloberes, Patricia |4 aut | |
| 700 | 1 | |a Mayos, Mercè |4 aut | |
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