A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury
Background The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that are clinically monitored in real time are lacking. The aim of the study was to test the hypothesis that end-tidal carbon dioxide ($ ETCO_{2} $) targeted pREBOA causes less metabolic disturbance compared to proximal systolic blood pressure (SBP) targeted pREBOA in a porcine model of hemorrhagic shock. Materials and methods Twenty anesthetized pigs (26–35 kg) were randomized to 45 min of either $ ETCO_{2} $ targeted pREBOA ($ pREBOA_{ETCO2} $, $ ETCO_{2} $ 90–110% of values before start of occlusion, n = 10) or proximal SBP targeted pREBOA ($ pREBOA_{SBP} $, SBP 80–100 mmHg, n = 10), during controlled grade IV hemorrhagic shock. Autotransfusion and reperfusion over 3 h followed. Hemodynamic and respiratory parameters, blood samples and jejunal specimens were analyzed. Results $ ETCO_{2} $ was significantly higher in the $ pREBOA_{ETCO2} $ group during the occlusion compared to the $ pREBOA_{SBP} $ group, whereas SBP, femoral arterial mean pressure and abdominal aortic blood flow were similar. During reperfusion, arterial and mesenteric lactate, plasma creatinine and plasma troponin concentrations were higher in the $ pREBOA_{SBP} $ group. Conclusions In a porcine model of hemorrhagic shock, $ ETCO_{2} $ targeted pREBOA caused less metabolic disturbance and end-organ damage compared to proximal SBP targeted pREBOA, with no disadvantageous hemodynamic impact. End-tidal $ CO_{2} $ should be investigated in clinical studies as a complementary clinical tool for mitigating ischemic–reperfusion injury when using pREBOA..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
|---|---|
| Enthalten in: |
Intensive Care Medicine Experimental - 11(2023), 1 vom: 10. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Stene Hurtsén, Anna [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
Balloon occlusion |
|---|
| Anmerkungen: |
© The Author(s) 2023 |
|---|
| doi: |
10.1186/s40635-023-00502-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR049991426 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR049991426 | ||
| 003 | DE-627 | ||
| 005 | 20230410064615.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230410s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s40635-023-00502-w |2 doi | |
| 035 | |a (DE-627)SPR049991426 | ||
| 035 | |a (SPR)s40635-023-00502-w-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Stene Hurtsén, Anna |e verfasserin |0 (orcid)0000-0003-0646-2508 |4 aut | |
| 245 | 1 | 2 | |a A randomized porcine study of hemorrhagic shock comparing end-tidal carbon dioxide targeted and proximal systolic blood pressure targeted partial resuscitative endovascular balloon occlusion of the aorta in the mitigation of metabolic injury |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) 2023 | ||
| 520 | |a Background The definition of partial resuscitative endovascular balloon occlusion of the aorta (pREBOA) is not yet determined and clinical markers of the degree of occlusion, metabolic effects and end-organ injury that are clinically monitored in real time are lacking. The aim of the study was to test the hypothesis that end-tidal carbon dioxide ($ ETCO_{2} $) targeted pREBOA causes less metabolic disturbance compared to proximal systolic blood pressure (SBP) targeted pREBOA in a porcine model of hemorrhagic shock. Materials and methods Twenty anesthetized pigs (26–35 kg) were randomized to 45 min of either $ ETCO_{2} $ targeted pREBOA ($ pREBOA_{ETCO2} $, $ ETCO_{2} $ 90–110% of values before start of occlusion, n = 10) or proximal SBP targeted pREBOA ($ pREBOA_{SBP} $, SBP 80–100 mmHg, n = 10), during controlled grade IV hemorrhagic shock. Autotransfusion and reperfusion over 3 h followed. Hemodynamic and respiratory parameters, blood samples and jejunal specimens were analyzed. Results $ ETCO_{2} $ was significantly higher in the $ pREBOA_{ETCO2} $ group during the occlusion compared to the $ pREBOA_{SBP} $ group, whereas SBP, femoral arterial mean pressure and abdominal aortic blood flow were similar. During reperfusion, arterial and mesenteric lactate, plasma creatinine and plasma troponin concentrations were higher in the $ pREBOA_{SBP} $ group. Conclusions In a porcine model of hemorrhagic shock, $ ETCO_{2} $ targeted pREBOA caused less metabolic disturbance and end-organ damage compared to proximal SBP targeted pREBOA, with no disadvantageous hemodynamic impact. End-tidal $ CO_{2} $ should be investigated in clinical studies as a complementary clinical tool for mitigating ischemic–reperfusion injury when using pREBOA. | ||
| 650 | 4 | |a Chock, hemorrhagic |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Balloon occlusion |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ischemia–reperfusion injury |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Carbon dioxide, Metabolism |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a McGreevy, David T. |4 aut | |
| 700 | 1 | |a Karlsson, Christina |4 aut | |
| 700 | 1 | |a Frostell, Claes G. |4 aut | |
| 700 | 1 | |a Hörer, Tal M. |4 aut | |
| 700 | 1 | |a Nilsson, Kristofer F. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Intensive Care Medicine Experimental |d Berlin : SpringerOpen, 2013 |g 11(2023), 1 vom: 10. Apr. |w (DE-627)SPR037075632 |w (DE-600)2740385-3 |x 2197-425X |7 nnns |
| 773 | 1 | 8 | |g volume:11 |g year:2023 |g number:1 |g day:10 |g month:04 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/s40635-023-00502-w |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 11 |j 2023 |e 1 |b 10 |c 04 | ||