Associations between an inflammatory diet index and severe non-alcoholic fatty liver disease: a prospective study of 171,544 UK Biobank participants
Background Although non-alcoholic fatty liver disease (NAFLD) is linked to inflammation, whether an inflammatory diet increases the risk of NAFLD is unclear. This study aimed to examine the association between the Energy-adjusted Diet Inflammatory Index (E-DII) score and severe NAFLD using UK Biobank. Methods This prospective cohort study included 171,544 UK Biobank participants. The E-DII score was computed using 18 food parameters. Associations between the E-DII and incident severe NAFLD (defined as hospital admission or death) were first investigated by E-DII categories (very/moderately anti-inflammatory [E-DII < − 1], neutral [E-DII − 1 to 1] and very/moderately pro-inflammatory [E-DII > 1]) using Cox proportional hazard models. Nonlinear associations were investigated using penalised cubic splines fitted into the Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. Results Over a median follow-up of 10.2 years, 1489 participants developed severe NAFLD. After adjusting for confounders, individuals in the very/moderately pro-inflammatory category had a higher risk (HR: 1.19 [95% CI: 1.03 to 1.38]) of incident severe NAFLD compared with those in the very/moderately anti-inflammatory category. There was some evidence of nonlinearity between the E-DII score and severe NAFLD. Conclusions Pro-inflammatory diets were associated with a higher risk of severe NAFLD independent of confounders such as the components of the metabolic syndrome. Considering there is no recommended treatment for the disease, our findings suggest a potential means to lower the risk of NAFLD..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
BMC medicine - 21(2023), 1 vom: 03. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Petermann-Rocha, Fanny [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Themen: |
Diet |
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| Anmerkungen: |
© The Author(s) 2023 |
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| doi: |
10.1186/s12916-023-02793-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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SPR049937138 |
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| 520 | |a Background Although non-alcoholic fatty liver disease (NAFLD) is linked to inflammation, whether an inflammatory diet increases the risk of NAFLD is unclear. This study aimed to examine the association between the Energy-adjusted Diet Inflammatory Index (E-DII) score and severe NAFLD using UK Biobank. Methods This prospective cohort study included 171,544 UK Biobank participants. The E-DII score was computed using 18 food parameters. Associations between the E-DII and incident severe NAFLD (defined as hospital admission or death) were first investigated by E-DII categories (very/moderately anti-inflammatory [E-DII < − 1], neutral [E-DII − 1 to 1] and very/moderately pro-inflammatory [E-DII > 1]) using Cox proportional hazard models. Nonlinear associations were investigated using penalised cubic splines fitted into the Cox proportional hazard models. Analyses were adjusted for sociodemographic, lifestyle and health-related factors. Results Over a median follow-up of 10.2 years, 1489 participants developed severe NAFLD. After adjusting for confounders, individuals in the very/moderately pro-inflammatory category had a higher risk (HR: 1.19 [95% CI: 1.03 to 1.38]) of incident severe NAFLD compared with those in the very/moderately anti-inflammatory category. There was some evidence of nonlinearity between the E-DII score and severe NAFLD. Conclusions Pro-inflammatory diets were associated with a higher risk of severe NAFLD independent of confounders such as the components of the metabolic syndrome. Considering there is no recommended treatment for the disease, our findings suggest a potential means to lower the risk of NAFLD. | ||
| 650 | 4 | |a Diet |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Non-alcoholic fatty liver disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Incidence |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prospective studies |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Wirth, Michael D. |4 aut | |
| 700 | 1 | |a Boonpor, Jirapitcha |4 aut | |
| 700 | 1 | |a Parra-Soto, Solange |4 aut | |
| 700 | 1 | |a Zhou, Ziyi |4 aut | |
| 700 | 1 | |a Mathers, John C. |4 aut | |
| 700 | 1 | |a Livingstone, Katherine |4 aut | |
| 700 | 1 | |a Forrest, Ewan |4 aut | |
| 700 | 1 | |a Pell, Jill P. |4 aut | |
| 700 | 1 | |a Ho, Frederick K. |4 aut | |
| 700 | 1 | |a Hébert, James R. |4 aut | |
| 700 | 1 | |a Celis-Morales, Carlos |4 aut | |
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