Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics
Purpose Metabolic changes during the perinatal period are known to promote obesity and type-2 diabetes in adulthood via perturbation of the microbiota. The risk factors for metabolic disorders include a high-fat diet (HFD) and exposure to pesticide residues. The objective of the present study was to evaluate the effects of perigestational exposure to a HFD and chlorpyrifos (CPF) on glycemia, lipid profiles, and microbial populations in Wistar dams and their female offspring. We also tested a preventive strategy based on treatment with the prebiotic inulin. Methods From 4 months before gestation to the end of the lactation period, six groups of dams were exposed to either a standard diet, a HFD alone, CPF alone, a combination of a HFD and CPF, and/or inulin supplementation. All female offspring were fed a standard diet from weaning to adulthood. We measured the impacts of these exposures on glycemia, the lipid profile, and the microbiota (composition, metabolite production, and translocation into tissues). Results HFD exposure and CPF + HFD co-exposure induced dysmetabolism and an imbalance in the gut flora in both the dams and the female offspring. Inulin mitigated the impact of exposure to a HFD alone but not that of CPF + HFD co-exposure. Conclusion Our results provide a better understanding of the complex interactions between environmental pollutants and diet in early life, including in the context of metabolic diseases..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
|---|---|
| Enthalten in: |
Zeitschrift für Ernährungswissenschaft - 62(2022), 3 vom: 13. Dez., Seite 1253-1265 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Djekkoun, Narimane [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Dysmetabolism |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s00394-022-03063-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR049766228 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR049766228 | ||
| 003 | DE-627 | ||
| 005 | 20230323113742.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230323s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00394-022-03063-y |2 doi | |
| 035 | |a (DE-627)SPR049766228 | ||
| 035 | |a (SPR)s00394-022-03063-y-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Djekkoun, Narimane |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Purpose Metabolic changes during the perinatal period are known to promote obesity and type-2 diabetes in adulthood via perturbation of the microbiota. The risk factors for metabolic disorders include a high-fat diet (HFD) and exposure to pesticide residues. The objective of the present study was to evaluate the effects of perigestational exposure to a HFD and chlorpyrifos (CPF) on glycemia, lipid profiles, and microbial populations in Wistar dams and their female offspring. We also tested a preventive strategy based on treatment with the prebiotic inulin. Methods From 4 months before gestation to the end of the lactation period, six groups of dams were exposed to either a standard diet, a HFD alone, CPF alone, a combination of a HFD and CPF, and/or inulin supplementation. All female offspring were fed a standard diet from weaning to adulthood. We measured the impacts of these exposures on glycemia, the lipid profile, and the microbiota (composition, metabolite production, and translocation into tissues). Results HFD exposure and CPF + HFD co-exposure induced dysmetabolism and an imbalance in the gut flora in both the dams and the female offspring. Inulin mitigated the impact of exposure to a HFD alone but not that of CPF + HFD co-exposure. Conclusion Our results provide a better understanding of the complex interactions between environmental pollutants and diet in early life, including in the context of metabolic diseases. | ||
| 650 | 4 | |a Dysmetabolism |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Perigestational period |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a High-fat diet |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pesticide |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Prebiotic |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Microbiota |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Depeint, Flore |4 aut | |
| 700 | 1 | |a Guibourdenche, Marion |4 aut | |
| 700 | 1 | |a Sabbouri, Hiba El Khayat Et |4 aut | |
| 700 | 1 | |a Corona, Aurélie |4 aut | |
| 700 | 1 | |a Rhazi, Larbi |4 aut | |
| 700 | 1 | |a Gay-Queheillard, Jerome |4 aut | |
| 700 | 1 | |a Rouabah, Leila |4 aut | |
| 700 | 1 | |a Biendo, Maurice |4 aut | |
| 700 | 1 | |a Al-Salameh, Abdallah |4 aut | |
| 700 | 1 | |a Lalau, Jean-Daniel |4 aut | |
| 700 | 1 | |a Bach, Véronique |4 aut | |
| 700 | 1 | |a Khorsi-Cauet, Hafida |0 (orcid)0000-0002-3411-4239 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Zeitschrift für Ernährungswissenschaft |d Darmstadt : Steinkopff, 1960 |g 62(2022), 3 vom: 13. Dez., Seite 1253-1265 |w (DE-627)SPR004842766 |w (DE-600)2164295-3 |x 1435-1293 |7 nnns |
| 773 | 1 | 8 | |g volume:62 |g year:2022 |g number:3 |g day:13 |g month:12 |g pages:1253-1265 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00394-022-03063-y |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 951 | |a AR | ||
| 952 | |d 62 |j 2022 |e 3 |b 13 |c 12 |h 1253-1265 | ||