Multi-element imaging of urinary stones by LA-ICP-MS with a homogeneous co-precipitation $ CaC_{2} %$ O_{4} $-matrix calibration standard
Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) studies on trace element concentration and their spatial distribution in $ CaC_{2} %$ O_{4} $-matrix urinary stones are important but powerfully rely on matrix-matched external calibration. In this work, $ CaC_{2} %$ O_{4} $ precipitate CaOx-1 which was doped with Mg, Cr, Mn, Fe, Co, Cu, Zn, and Sr was prepared by the homogeneous co-precipitation method. It had a homogeneous distribution of major (RSD of 0.46%) and trace elements (RSD of 1.83–6.92%) due to the negligible concentration difference compared with that prepared by the heterogeneous co-precipitation method. Based on this, an analytical method for quantitative determination of elemental concentration in $ CaC_{2} %$ O_{4} $-matrix samples was established using CaOx-1 as a calibration standard, and the accuracy of this method was assessed by calibrating the elemental concentration in another synthetic $ CaC_{2} %$ O_{4} $ precipitate CaOx-2 with relative deviation (Dr) from − 11.43% (Mn) to 9.76% (Mg). Finally, a methodology for quantitative imaging of Mg, Cr, Mn, Fe, Co, Cu, Zn, and Sr in urinary stones via LA-ICP-MS was developed. From the elemental distributional maps, an annular texture can be found for Mg, Cu, Zn, and Sr, which corresponds to the annular white and brown texture in the real urinary stone. A homogeneous distribution of Fe and low concentrations of Cr and Co were found throughout the stone, while Mn was highly concentrated in the margin of the stone. All these results demonstrate that quantitative distribution patterns of Mg, Cr, Mn, Fe, Co, Cu, Zn, and Sr can be obtained by LA-ICP-MS using CaOx-1 as a calibration standard, which can provide potential evidence for urological and other medical studies. Graphical Abstract.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:415 |
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| Enthalten in: |
Analytical and bioanalytical chemistry - 415(2023), 9 vom: 11. Feb., Seite 1751-1764 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Deng, Hao [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
CaOx-1 |
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| Anmerkungen: |
© Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s00216-023-04576-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) studies on trace element concentration and their spatial distribution in $ CaC_{2} %$ O_{4} $-matrix urinary stones are important but powerfully rely on matrix-matched external calibration. In this work, $ CaC_{2} %$ O_{4} $ precipitate CaOx-1 which was doped with Mg, Cr, Mn, Fe, Co, Cu, Zn, and Sr was prepared by the homogeneous co-precipitation method. It had a homogeneous distribution of major (RSD of 0.46%) and trace elements (RSD of 1.83–6.92%) due to the negligible concentration difference compared with that prepared by the heterogeneous co-precipitation method. Based on this, an analytical method for quantitative determination of elemental concentration in $ CaC_{2} %$ O_{4} $-matrix samples was established using CaOx-1 as a calibration standard, and the accuracy of this method was assessed by calibrating the elemental concentration in another synthetic $ CaC_{2} %$ O_{4} $ precipitate CaOx-2 with relative deviation (Dr) from − 11.43% (Mn) to 9.76% (Mg). Finally, a methodology for quantitative imaging of Mg, Cr, Mn, Fe, Co, Cu, Zn, and Sr in urinary stones via LA-ICP-MS was developed. From the elemental distributional maps, an annular texture can be found for Mg, Cu, Zn, and Sr, which corresponds to the annular white and brown texture in the real urinary stone. A homogeneous distribution of Fe and low concentrations of Cr and Co were found throughout the stone, while Mn was highly concentrated in the margin of the stone. All these results demonstrate that quantitative distribution patterns of Mg, Cr, Mn, Fe, Co, Cu, Zn, and Sr can be obtained by LA-ICP-MS using CaOx-1 as a calibration standard, which can provide potential evidence for urological and other medical studies. Graphical Abstract | ||
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| 650 | 4 | |a Urinary stone |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Calcium oxalate |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Yang, Wanqing |4 aut | |
| 700 | 1 | |a Hu, Mian |4 aut | |
| 700 | 1 | |a Zhang, Yu |4 aut | |
| 700 | 1 | |a Ke, Yuqiu |0 (orcid)0000-0002-0874-558X |4 aut | |
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