COVID-associated rhinocerebral mucormycosis: a retrospective analysis of presentation and outcomes
Objectives To comprehensively analyse the disease presentation and mortality of COVID-associated rhino-orbito-cerebral mucormycosis. Methods A retrospective analysis of the demographics, clinical and radiographic findings was performed. A binary logistic regression analysis was performed to examine the survival of patients with mucormycosis from hypothesised predictors. Results A total of 202 patients were included in this study. Statistical significance was demonstrated in the predilection to the male gender, recent history of SARS-COV-2, history of use of corticosteroid and hyperglycemia in this cohort of CAM. The mortality rate was 18.31%. Advanced age, raised HbA1c and intra-orbital extension were found to be predictors adversely affecting survival. Conclusion Early diagnosis, aggressive surgical therapy, early and appropriate medical therapy can help improve outcomes. Level of evidence Level 4..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:280 |
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| Enthalten in: |
European archives of oto-rhino-laryngology and head & neck - 280(2022), 2 vom: 18. Juli, Seite 713-721 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Moorthy, Aditya [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
CAM |
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| Anmerkungen: |
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
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| doi: |
10.1007/s00405-022-07544-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR049081004 |
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| 520 | |a Objectives To comprehensively analyse the disease presentation and mortality of COVID-associated rhino-orbito-cerebral mucormycosis. Methods A retrospective analysis of the demographics, clinical and radiographic findings was performed. A binary logistic regression analysis was performed to examine the survival of patients with mucormycosis from hypothesised predictors. Results A total of 202 patients were included in this study. Statistical significance was demonstrated in the predilection to the male gender, recent history of SARS-COV-2, history of use of corticosteroid and hyperglycemia in this cohort of CAM. The mortality rate was 18.31%. Advanced age, raised HbA1c and intra-orbital extension were found to be predictors adversely affecting survival. Conclusion Early diagnosis, aggressive surgical therapy, early and appropriate medical therapy can help improve outcomes. Level of evidence Level 4. | ||
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