Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has transformed health systems worldwide. There is conflicting data regarding the degree of cardiovascular involvement following infection. A registry was designed to evaluate the prevalence of echocardiographic abnormalities in adults recovered from COVID-19. We prospectively evaluated 595 participants (mean age 45.5 ± 14.9 years; 50.8% female) from 10 institutions in Argentina and Brazil. Median time between infection and evaluation was two months, and 82.5% of participants were not hospitalized for their infection. Echocardiographic studies were conducted with General Electric equipment; 2DE imaging and global longitudinal strain (GLS) of both ventricles were performed. A total of 61.7% of the participants denied relevant cardiovascular history and 41.8% had prolonged symptoms after resolution of COVID-19 infection. Mean left ventricular ejection fraction (LVEF) was 61.0 ± 5.5% overall. In patients without prior comorbidities, 8.2% had some echocardiographic abnormality: 5.7% had reduced GLS, 3.0% had a LVEF below normal range, and 1.1% had wall motion abnormalities. The right ventricle (RV) was dilated in 1.6% of participants, 3.1% had a reduced GLS, and 0.27% had reduced RV function. Mild pericardial effusion was observed in 0.82% of participants. Male patients were more likely to have new echocardiographic abnormalities (OR 2.82, p = 0.002). Time elapsed since infection resolution (p = 0.245), presence of symptoms (p = 0.927), or history of hospitalization during infection (p = 0.671) did not have any correlation with echocardiographic abnormalities. Cardiovascular abnormalities after COVID-19 infection are rare and usually mild, especially following mild infection, being a low GLS of left and right ventricle, the most common ones in our registry. Post COVID cardiac abnormalities may be more frequent among males..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:39 |
|---|---|
| Enthalten in: |
The international journal of cardiovascular imaging - 39(2022), 1 vom: 13. Aug., Seite 77-85 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Garcia-Zamora, Sebastián [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
|---|
| doi: |
10.1007/s10554-022-02706-9 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR048976512 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR048976512 | ||
| 003 | DE-627 | ||
| 005 | 20230519074542.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230105s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10554-022-02706-9 |2 doi | |
| 035 | |a (DE-627)SPR048976512 | ||
| 035 | |a (SPR)s10554-022-02706-9-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Garcia-Zamora, Sebastián |e verfasserin |0 (orcid)0000-0001-6846-0247 |4 aut | |
| 245 | 1 | 0 | |a Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Nature B.V. 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has transformed health systems worldwide. There is conflicting data regarding the degree of cardiovascular involvement following infection. A registry was designed to evaluate the prevalence of echocardiographic abnormalities in adults recovered from COVID-19. We prospectively evaluated 595 participants (mean age 45.5 ± 14.9 years; 50.8% female) from 10 institutions in Argentina and Brazil. Median time between infection and evaluation was two months, and 82.5% of participants were not hospitalized for their infection. Echocardiographic studies were conducted with General Electric equipment; 2DE imaging and global longitudinal strain (GLS) of both ventricles were performed. A total of 61.7% of the participants denied relevant cardiovascular history and 41.8% had prolonged symptoms after resolution of COVID-19 infection. Mean left ventricular ejection fraction (LVEF) was 61.0 ± 5.5% overall. In patients without prior comorbidities, 8.2% had some echocardiographic abnormality: 5.7% had reduced GLS, 3.0% had a LVEF below normal range, and 1.1% had wall motion abnormalities. The right ventricle (RV) was dilated in 1.6% of participants, 3.1% had a reduced GLS, and 0.27% had reduced RV function. Mild pericardial effusion was observed in 0.82% of participants. Male patients were more likely to have new echocardiographic abnormalities (OR 2.82, p = 0.002). Time elapsed since infection resolution (p = 0.245), presence of symptoms (p = 0.927), or history of hospitalization during infection (p = 0.671) did not have any correlation with echocardiographic abnormalities. Cardiovascular abnormalities after COVID-19 infection are rare and usually mild, especially following mild infection, being a low GLS of left and right ventricle, the most common ones in our registry. Post COVID cardiac abnormalities may be more frequent among males. | ||
| 650 | 4 | |a Echocardiography |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a COVID-19 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Myocarditis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Diagnostic imaging |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ventricular remodeling |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Humans |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Picco, José M. |4 aut | |
| 700 | 1 | |a Lepori, Augusto J. |4 aut | |
| 700 | 1 | |a Galello, Marcela I. |4 aut | |
| 700 | 1 | |a Saad, Ariel K. |4 aut | |
| 700 | 1 | |a Ayón, Miguel |4 aut | |
| 700 | 1 | |a Monga-Aguilar, Nancy |4 aut | |
| 700 | 1 | |a Shehadeh, Issam |4 aut | |
| 700 | 1 | |a Manganiello, Carlos F. |4 aut | |
| 700 | 1 | |a Izaguirre, Cintia |4 aut | |
| 700 | 1 | |a Fallabrino, Luciano N. |4 aut | |
| 700 | 1 | |a Clavero, Matias |4 aut | |
| 700 | 1 | |a Mansur, Flavia |4 aut | |
| 700 | 1 | |a Ghibaudo, Sebastián |4 aut | |
| 700 | 1 | |a Sevilla, Daniela |4 aut | |
| 700 | 1 | |a Cado, Cesar A. |4 aut | |
| 700 | 1 | |a Priotti, Mauricio |4 aut | |
| 700 | 1 | |a Liblik, Kiera |4 aut | |
| 700 | 1 | |a Gastaldello, Natalio |4 aut | |
| 700 | 1 | |a Merlo, Pablo M. |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The international journal of cardiovascular imaging |d Dordrecht [u.a.] : Springer, 1985 |g 39(2022), 1 vom: 13. Aug., Seite 77-85 |w (DE-627)SPR011226935 |w (DE-600)2008950-8 |x 1573-0743 |7 nnns |
| 773 | 1 | 8 | |g volume:39 |g year:2022 |g number:1 |g day:13 |g month:08 |g pages:77-85 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s10554-022-02706-9 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 39 |j 2022 |e 1 |b 13 |c 08 |h 77-85 | ||