Oxidative Stress Indices Changes in the Hearts of Rat Pups in Response to Maternal Buprenorphine Treatment during Gestation and Lactation
Abstract This study aimed to assess the effects of Buprenorphine (BUP) on oxidative parameters in pups born to mothers exposed to the drug during gestation and lactation. Pregnant and lactating rats received BUP, 0.5 or 0.1 mg/kg subcutaneously for 21 and 28 days, respectively. At the end of the study, the pups were anesthetized, and the hearts were dissected out to measure oxidative stress indices, including the levels of Malondialdehyde (MDA), Nitric oxide (NO), Glutathione (GSH), and the activity of Superoxide dismutase (SOD). Our findings indicated that BUP did not alter MDA, NO, GSH levels, nor SOD activity in the cardiac tissue of pups exposed to this drug during the fetal period and through breast milk. We suggest performing additional studies to determine the association between BUP and oxidative modifications in cardiac tissues of pups born to mothers under BUP therapy during gestation and lactation..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
|---|---|
| Enthalten in: |
Cardiovascular toxicology - 22(2021), 1 vom: 01. Okt., Seite 29-34 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Aramjoo, Hamed [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Buprenorphine |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 |
|---|
| doi: |
10.1007/s12012-021-09686-7 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR045910995 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR045910995 | ||
| 003 | DE-627 | ||
| 005 | 20230519223056.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220107s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12012-021-09686-7 |2 doi | |
| 035 | |a (DE-627)SPR045910995 | ||
| 035 | |a (SPR)s12012-021-09686-7-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Aramjoo, Hamed |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Oxidative Stress Indices Changes in the Hearts of Rat Pups in Response to Maternal Buprenorphine Treatment during Gestation and Lactation |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 | ||
| 520 | |a Abstract This study aimed to assess the effects of Buprenorphine (BUP) on oxidative parameters in pups born to mothers exposed to the drug during gestation and lactation. Pregnant and lactating rats received BUP, 0.5 or 0.1 mg/kg subcutaneously for 21 and 28 days, respectively. At the end of the study, the pups were anesthetized, and the hearts were dissected out to measure oxidative stress indices, including the levels of Malondialdehyde (MDA), Nitric oxide (NO), Glutathione (GSH), and the activity of Superoxide dismutase (SOD). Our findings indicated that BUP did not alter MDA, NO, GSH levels, nor SOD activity in the cardiac tissue of pups exposed to this drug during the fetal period and through breast milk. We suggest performing additional studies to determine the association between BUP and oxidative modifications in cardiac tissues of pups born to mothers under BUP therapy during gestation and lactation. | ||
| 650 | 4 | |a Buprenorphine |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Oxidative stress parameters |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Lactation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gestation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Rat |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pup |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Yousefizadeh, Shahnaz |4 aut | |
| 700 | 1 | |a Aschner, Michael |4 aut | |
| 700 | 1 | |a Roshanravan, Babak |4 aut | |
| 700 | 1 | |a Farkhondeh, Tahereh |4 aut | |
| 700 | 1 | |a Samarghandian, Saeed |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cardiovascular toxicology |d [S.l.] : Springer US, 2001 |g 22(2021), 1 vom: 01. Okt., Seite 29-34 |w (DE-627)SPR023650184 |w (DE-600)2072576-0 |x 1559-0259 |7 nnns |
| 773 | 1 | 8 | |g volume:22 |g year:2021 |g number:1 |g day:01 |g month:10 |g pages:29-34 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s12012-021-09686-7 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 22 |j 2021 |e 1 |b 01 |c 10 |h 29-34 | ||