Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19): relationship with mortality
Background Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. Methods Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered. Results Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8–12.6; p < 0.001); coronary artery disease (OR: 2.4; 95% CI 1.4–5.0; p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28–0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59–4.65; p < 0.001), age (HR: 1.035; 95% CI 1.014–1.057; p = 0.001), and albumin (HR: 0.447; 95% CI 0.277–0.723; p = 0.001) predicted morality. Conclusions Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
---|---|
Enthalten in: |
Internal and emergency medicine - 16(2021), 5 vom: 04. Juli, Seite 1231-1237 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Violi, Francesco [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
BKL: | |
---|---|
Themen: |
Anmerkungen: |
© The Author(s) 2021 |
---|
doi: |
10.1007/s11739-020-02621-8 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
SPR044655843 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | SPR044655843 | ||
003 | DE-627 | ||
005 | 20230519234224.0 | ||
007 | cr uuu---uuuuu | ||
008 | 210725s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s11739-020-02621-8 |2 doi | |
035 | |a (DE-627)SPR044655843 | ||
035 | |a (SPR)s11739-020-02621-8-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q ASE |
084 | |a 44.80 |2 bkl | ||
100 | 1 | |a Violi, Francesco |e verfasserin |4 aut | |
245 | 1 | 0 | |a Arterial and venous thrombosis in coronavirus 2019 disease (Covid-19): relationship with mortality |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a © The Author(s) 2021 | ||
520 | |a Background Patients with coronavirus disease 2019 (Covid-19) may experience venous thrombosis while data regarding arterial thrombosis are sparse. Methods Prospective multicenter study in 5 hospitals including 373 patients with Covid-19-related pneumonia. Demographic data, laboratory findings including coagulation tests and comorbidities were reported. During the follow-up any arterial or venous thrombotic events and death were registered. Results Among 373 patients, 75 (20%) had a thrombotic event and 75 (20%) died. Thrombotic events included 41 venous thromboembolism and 34 arterial thrombosis. Age, cardiovascular disease, intensive care unit treatment, white blood cells, D-dimer, albumin and troponin blood levels were associated with thrombotic events. In a multivariable regression logistic model, intensive care unit treatment (Odds Ratio [OR]: 6.0; 95% Confidence Interval [CI] 2.8–12.6; p < 0.001); coronary artery disease (OR: 2.4; 95% CI 1.4–5.0; p = 0.022); and albumin levels (OR: 0.49; 95% CI 0.28–0.87; p = 0.014) were associated with ischemic events. Age, sex, chronic obstructive pulmonary disease, diabetes, heart failure, coronary heart disease, intensive care unit treatment, in-hospital thrombotic events, D-dimer, C-reactive protein, troponin, and albumin levels were associated with mortality. A multivariable Cox regression analysis showed that in-hospital thrombotic events (hazard ratio [HR]: 2.72; 95% CI 1.59–4.65; p < 0.001), age (HR: 1.035; 95% CI 1.014–1.057; p = 0.001), and albumin (HR: 0.447; 95% CI 0.277–0.723; p = 0.001) predicted morality. Conclusions Covid-19 patients experience an equipollent rate of venous and arterial thrombotic events, that are associated with poor survival. Early identification and appropriate treatment of Covid-19 patients at risk of thrombosis may improve prognosis. | ||
650 | 4 | |a Covid-19 |7 (dpeaa)DE-He213 | |
650 | 4 | |a SARS-cov-2 |7 (dpeaa)DE-He213 | |
650 | 4 | |a Thrombosis |7 (dpeaa)DE-He213 | |
650 | 4 | |a Mortality |7 (dpeaa)DE-He213 | |
700 | 1 | |a Ceccarelli, Giancarlo |e verfasserin |4 aut | |
700 | 1 | |a Cangemi, Roberto |e verfasserin |4 aut | |
700 | 1 | |a Cipollone, Francesco |e verfasserin |4 aut | |
700 | 1 | |a D’Ardes, Damiano |e verfasserin |4 aut | |
700 | 1 | |a Oliva, Alessandra |e verfasserin |4 aut | |
700 | 1 | |a Pirro, Matteo |e verfasserin |4 aut | |
700 | 1 | |a Rocco, Monica |e verfasserin |4 aut | |
700 | 1 | |a Alessandri, Francesco |e verfasserin |4 aut | |
700 | 1 | |a D’Ettorre, Gabriella |e verfasserin |4 aut | |
700 | 1 | |a Lichtner, Miriam |e verfasserin |4 aut | |
700 | 1 | |a Pignatelli, Pasquale |e verfasserin |4 aut | |
700 | 1 | |a Ferro, Domenico |e verfasserin |4 aut | |
700 | 1 | |a Ruberto, Franco |e verfasserin |4 aut | |
700 | 1 | |a Lip, Gregory Y. H. |e verfasserin |4 aut | |
700 | 1 | |a Pugliese, Francesco |e verfasserin |4 aut | |
700 | 1 | |a Mastroianni, Claudio Maria |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Internal and emergency medicine |d Milan : Springer Milan, 2006 |g 16(2021), 5 vom: 04. Juli, Seite 1231-1237 |w (DE-627)SPR022112723 |w (DE-600)2378342-4 |x 1970-9366 |7 nnns |
773 | 1 | 8 | |g volume:16 |g year:2021 |g number:5 |g day:04 |g month:07 |g pages:1231-1237 |
856 | 4 | 0 | |u https://dx.doi.org/10.1007/s11739-020-02621-8 |z kostenfrei |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_SPRINGER | ||
912 | |a SSG-OLC-PHA | ||
936 | b | k | |a 44.80 |q ASE |
951 | |a AR | ||
952 | |d 16 |j 2021 |e 5 |b 04 |c 07 |h 1231-1237 |