Ferumoxytol-enhanced ultrashort TE MRA and quantitative morphometry of the human kidney vasculature
Purpose To evaluate the feasibility of Quantitative Ultrashort-Time-to-Echo Contrast-Enhanced (QUTE-CE) MRA using ferumoxytol as a contrast agent for abdominal angiography in the kidney. Methods Four subjects underwent ferumoxytol-enhanced MRA with the 3D UTE Spiral VIBE WIP sequence at 3 T. Image quality metrics were quantified, specifically the blood Signal-to-Noise Ratio (SNR), blood-tissue Contrast-to-Noise Ratio (CNR) and Intraluminal Signal Heterogeneity (ISH) from both the aorta and inferior vena cava (IVC). Morphometric analysis of the vessels was performed using manual approach and semi-automatic approach using Vascular Modeling ToolKit (VMTK). Image quality and branching order were compared between QUTE-CE MRA and the Gadolinium (Gd) CEMRA reference image. Results QUTE-CE MRA provides a bright blood snapshot that delineates arteries and veins equally in the same scan. The maximum SNR and CNR values were 3,282 ± 1,218 and 1,295 ± 580, respectively – significantly higher than available literature values using other CEMRA techniques. QUTE-CE MRA had lower ISH and depicted higher vessel branching order (7th vs 3rd) within the kidney compared to a standard dynamic clinical Gd CEMRA scan. Morphometric analysis yielded quantitative results for the total kidney volume, total cyst volume and for diameters of the branching arterial network down to the $ 7^{th} $ branch. Vessel curvature was significantly increased (p < 0.001) in the presence of a renal cyst compared to equivalent vessels in normal kidney regions. Conclusion QUTE-CE MRA is feasible for kidney angiography, providing greater detail of kidney vasculature, enabling quantitative morphometric analysis of the abdominal and intra-renal vessels and yielding metrics relevant to vascular diseases while using a contrast agent ferumoxytol that is safe for CKD patients..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Abdominal radiology - 46(2021), 7 vom: 05. März, Seite 3288-3300 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Timms, Liam [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Chronic kidney disease |
|---|
| Anmerkungen: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 |
|---|
| doi: |
10.1007/s00261-021-02984-2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR044354428 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR044354428 | ||
| 003 | DE-627 | ||
| 005 | 20230519085941.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210621s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00261-021-02984-2 |2 doi | |
| 035 | |a (DE-627)SPR044354428 | ||
| 035 | |a (SPR)s00261-021-02984-2-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q ASE |
| 082 | 0 | 4 | |a 610 |q ASE |
| 100 | 1 | |a Timms, Liam |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Ferumoxytol-enhanced ultrashort TE MRA and quantitative morphometry of the human kidney vasculature |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 | ||
| 520 | |a Purpose To evaluate the feasibility of Quantitative Ultrashort-Time-to-Echo Contrast-Enhanced (QUTE-CE) MRA using ferumoxytol as a contrast agent for abdominal angiography in the kidney. Methods Four subjects underwent ferumoxytol-enhanced MRA with the 3D UTE Spiral VIBE WIP sequence at 3 T. Image quality metrics were quantified, specifically the blood Signal-to-Noise Ratio (SNR), blood-tissue Contrast-to-Noise Ratio (CNR) and Intraluminal Signal Heterogeneity (ISH) from both the aorta and inferior vena cava (IVC). Morphometric analysis of the vessels was performed using manual approach and semi-automatic approach using Vascular Modeling ToolKit (VMTK). Image quality and branching order were compared between QUTE-CE MRA and the Gadolinium (Gd) CEMRA reference image. Results QUTE-CE MRA provides a bright blood snapshot that delineates arteries and veins equally in the same scan. The maximum SNR and CNR values were 3,282 ± 1,218 and 1,295 ± 580, respectively – significantly higher than available literature values using other CEMRA techniques. QUTE-CE MRA had lower ISH and depicted higher vessel branching order (7th vs 3rd) within the kidney compared to a standard dynamic clinical Gd CEMRA scan. Morphometric analysis yielded quantitative results for the total kidney volume, total cyst volume and for diameters of the branching arterial network down to the $ 7^{th} $ branch. Vessel curvature was significantly increased (p < 0.001) in the presence of a renal cyst compared to equivalent vessels in normal kidney regions. Conclusion QUTE-CE MRA is feasible for kidney angiography, providing greater detail of kidney vasculature, enabling quantitative morphometric analysis of the abdominal and intra-renal vessels and yielding metrics relevant to vascular diseases while using a contrast agent ferumoxytol that is safe for CKD patients. | ||
| 650 | 4 | |a Ultrashort time-to-echo |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Ferumoxytol |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Chronic kidney disease |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a MRA |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Vascular |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Zhou, Tianyi |e verfasserin |4 aut | |
| 700 | 1 | |a Lyu, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Qiao, Ju |e verfasserin |4 aut | |
| 700 | 1 | |a Mishra, Vishala |e verfasserin |4 aut | |
| 700 | 1 | |a Lahoud, Rita Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Jayaraman, Gayatri Veeramani |e verfasserin |4 aut | |
| 700 | 1 | |a Allegretti, Andrew S. |e verfasserin |4 aut | |
| 700 | 1 | |a Drew, David |e verfasserin |4 aut | |
| 700 | 1 | |a Seethamraju, Ravi T. |e verfasserin |4 aut | |
| 700 | 1 | |a Harisinghani, Mukesh |e verfasserin |4 aut | |
| 700 | 1 | |a Sridhar, Srinivas |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Abdominal radiology |d [Boston, MA] : Springer US, 2016 |g 46(2021), 7 vom: 05. März, Seite 3288-3300 |w (DE-627)SPR003173186 |w (DE-600)2845742-0 |x 2366-0058 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2021 |g number:7 |g day:05 |g month:03 |g pages:3288-3300 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00261-021-02984-2 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2021 |e 7 |b 05 |c 03 |h 3288-3300 | ||