Improved Chemosensitization Activity of Carboxymethyl Chitosan/PVA Hydrogels by Plasma Surface Modification
Abstract As global population escalates; the need for better healthcare shall inevitably intensify. Current scenario, thus, calls for a versatile technology for the construction for smart biomaterials to cater to the needs. In this context; hydrogels comprising carboxymethyl chitosan and polyvinyl alcohol (CMCS/ PVA) were fabricated using a green crosslinker, tetraethyl orthosilicate. To enhance their bio-efficacy; cold plasma assisted surface tailoring of the aforesaid hydrogels was performed as a function of four different gases viz Air, Ar, He and $ N_{2} $. Apart from improving the surface wettability; plasma treatment endowed the hydrogels with an improved tensile strength. 5-Fluorouracil (5FU) release studies from the hydrogels validated their potential as oral colon-targeted delivery systems. Hemolytic experiments revealed no adverse effect on RBCs post-plasma treatment. Pristine hydrogels exhibited good cytocompatibility with MCF-7 cells. A strong cell growth inhibition was observed from 5FU-loaded hydrogels as validated by caspase-3 assay. Further assessment by the soil burial test revealed the hydrogels were biodegradable. Among all, the Ar-plasma treated hydrogel demonstrated superior hemocompatibility, chemosensitivity and biodegradability. Thus, cold plasma technology has invariably paved the path as an eco-friendly, economical and effectual strategy for development of novel CMCS/ PVA hydrogels in anticancer therapy..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of polymers and the environment - 29(2021), 5 vom: 01. Jan., Seite 1663-1679 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dalei, Ganeswar [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
Carboxymethyl chitosan |
| doi: |
10.1007/s10924-020-02007-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract As global population escalates; the need for better healthcare shall inevitably intensify. Current scenario, thus, calls for a versatile technology for the construction for smart biomaterials to cater to the needs. In this context; hydrogels comprising carboxymethyl chitosan and polyvinyl alcohol (CMCS/ PVA) were fabricated using a green crosslinker, tetraethyl orthosilicate. To enhance their bio-efficacy; cold plasma assisted surface tailoring of the aforesaid hydrogels was performed as a function of four different gases viz Air, Ar, He and $ N_{2} $. Apart from improving the surface wettability; plasma treatment endowed the hydrogels with an improved tensile strength. 5-Fluorouracil (5FU) release studies from the hydrogels validated their potential as oral colon-targeted delivery systems. Hemolytic experiments revealed no adverse effect on RBCs post-plasma treatment. Pristine hydrogels exhibited good cytocompatibility with MCF-7 cells. A strong cell growth inhibition was observed from 5FU-loaded hydrogels as validated by caspase-3 assay. Further assessment by the soil burial test revealed the hydrogels were biodegradable. Among all, the Ar-plasma treated hydrogel demonstrated superior hemocompatibility, chemosensitivity and biodegradability. Thus, cold plasma technology has invariably paved the path as an eco-friendly, economical and effectual strategy for development of novel CMCS/ PVA hydrogels in anticancer therapy. | ||
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| 700 | 1 | |a Samanta, Luna |e verfasserin |4 aut | |
| 700 | 1 | |a Das, Smruti Prava |e verfasserin |4 aut | |
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