Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis
Purpose We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). Methods The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis. Results We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND. Conclusion TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
|---|---|
| Enthalten in: |
Surgery today - 51(2020), 4 vom: 14. Okt., Seite 595-604 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yokotani, Tomoyo [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| BKL: | |
|---|---|
| Themen: |
Axillary dissection |
| doi: |
10.1007/s00595-020-02157-6 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR043538517 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR043538517 | ||
| 003 | DE-627 | ||
| 005 | 20230519230103.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210320s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00595-020-02157-6 |2 doi | |
| 035 | |a (DE-627)SPR043538517 | ||
| 035 | |a (DE-599)SPRs00595-020-02157-6-e | ||
| 035 | |a (SPR)s00595-020-02157-6-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q ASE |
| 082 | 0 | 4 | |a 610 |q ASE |
| 084 | |a 44.65 |2 bkl | ||
| 100 | 1 | |a Yokotani, Tomoyo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictive value of tumor-infiltrating lymphocytes for pathological response to neoadjuvant chemotherapy in breast cancer patients with axillary lymph node metastasis |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Purpose We investigated the role of tumor-infiltrating lymphocytes (TILs) in pretreatment primary breast cancer to predict pathological response to neoadjuvant chemotherapy (NAC) in patients with clinical node-positive disease (cN +). Methods The subjects of this study were 60 patients with cN + , who received NAC followed by breast surgery with axillary lymph node dissection (ALND). We conducted a semi-quantitative assessment of TILs in pretreatment primary tumors and their association with clinicopathological factors and axillary lymph node metastasis. Results We observed a higher number of TILs in tumors with negative hormone receptors, positive human epidermal growth factor receptor 2, or high Ki67. TILs were associated with a favorable response to NAC in primary tumors. The rate of axillary pathologic complete response (Ax-pCR) was significantly higher in patients with a high number of TILs than in patients with a low number of TILs (72.0% versus 17.1%, p < 0.001). In multivariable analysis, a high number of TILs was a significant predictor of Ax-pCR as well as of pCR of the primary tumor after NAC. Importantly, all patients with HER2-positive tumors in the high TILs group showed Ax-pCR on ALND. Conclusion TILs in pretreatment primary breast cancer had the potential to predict therapeutic efficacy of NAC in patients with clinical node-positive disease. | ||
| 650 | 4 | |a Tumor-infiltrating lymphocytes |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Axillary dissection |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Breast cancer |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Neoadjuvant chemotherapy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Axillary pathological complete response |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ikeda, Noaya |e verfasserin |4 aut | |
| 700 | 1 | |a Hirao, Tomoko |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Yukimi |e verfasserin |4 aut | |
| 700 | 1 | |a Morita, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Fujii, Tomomi |e verfasserin |4 aut | |
| 700 | 1 | |a Ohbayashi, Chiho |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Toyoki |e verfasserin |4 aut | |
| 700 | 1 | |a Sho, Masayuki |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Surgery today |d Tokyo : Springer, 1971 |g 51(2020), 4 vom: 14. Okt., Seite 595-604 |w (DE-627)SPR007004028 |w (DE-600)1463169-6 |x 1436-2813 |7 nnns |
| 773 | 1 | 8 | |g volume:51 |g year:2020 |g number:4 |g day:14 |g month:10 |g pages:595-604 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s00595-020-02157-6 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 44.65 |q ASE |
| 951 | |a AR | ||
| 952 | |d 51 |j 2020 |e 4 |b 14 |c 10 |h 595-604 | ||