Right ventricular diastolic function in aging: a head-to-head comparison between phase-contrast MRI and Doppler echocardiography
Abstract To evaluate right ventricle (RV) diastolic function from phase-contrast MRI (PC-MRI) in aging. 89 healthy individuals (50 men, 43 ± 15 years) underwent cardiac MRI including 2D PC-MRI (1.5T) and reference Doppler echocardiography of both ventricles on the same day. Conventional echocardiographic parameters were estimated: early (E, cm/s) and atrial (A) peak velocities as well as myocardial early peak longitudinal velocity (E′). PC-MRI images were analyzed using custom software, providing: E′, E and A waves along with respective peak flow rates (Ef, Af, mL/s) and filling volume (mL), for both ventricles. Intra- and inter-observer reproducibility was studied in 30 subjects and coefficients of variation (CoV) as well as intra-class correlation coefficients (ICC) were provided. RV diastolic function indices derived from PC-MRI data were reproducible (CoV ≤ 21%, ICC ≥ 0.75) and reliable as reflected by significant associations with left ventricular diastolic function indices assessed using both echocardiography (linear regression Pearson correlation coefficient r ≤ 0.59) and PC-MRI (r ≤ 71). Despite the fair associations between RV echocardiography and PC-MRI (r ≤ 0.25), the highest correlation with age was obtained for MRI Ef/Af ratio (r = − 0.64, p < 0.0001 vs. r = − 0.40, p = 0.0001 for echocardiographic E/A). Among PC-MRI E/A ratios, highest correlations with age were observed for flow rate and mean velocity ratios (r = − 0.61, p < 0.0001) as compared to maximal velocity ratios (r = − 0.56, p < 0.0001). Associations with age for E′ were equivalent between PC-MRI (mean velocity: r = − 0.40, p < 0.0001; maximal velocity: r = − 0.36, p = 0.0005) and echocardiography (r = − 0.36, p = 0.0006). Finally, the significant and age-independent associations between RV mass/end-diastolic volume and E′ were stronger for PC-MRI (mean velocity: r = − 0.36, p = 0.0006; maximal velocity: r = − 0.28, p = 0.007) than echocardiography (r = − 0.09, p = 0.38). PC-MRI tricuspid inflow and annulus myocardial velocity parameters were reproducible and able to characterize age-related variations in RV diastolic function..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
The international journal of cardiovascular imaging - 37(2020), 2 vom: 27. Sept., Seite 663-674 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kachenoura, Nadjia [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
| doi: |
10.1007/s10554-020-02040-y |
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SPR043271367 |
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| 520 | |a Abstract To evaluate right ventricle (RV) diastolic function from phase-contrast MRI (PC-MRI) in aging. 89 healthy individuals (50 men, 43 ± 15 years) underwent cardiac MRI including 2D PC-MRI (1.5T) and reference Doppler echocardiography of both ventricles on the same day. Conventional echocardiographic parameters were estimated: early (E, cm/s) and atrial (A) peak velocities as well as myocardial early peak longitudinal velocity (E′). PC-MRI images were analyzed using custom software, providing: E′, E and A waves along with respective peak flow rates (Ef, Af, mL/s) and filling volume (mL), for both ventricles. Intra- and inter-observer reproducibility was studied in 30 subjects and coefficients of variation (CoV) as well as intra-class correlation coefficients (ICC) were provided. RV diastolic function indices derived from PC-MRI data were reproducible (CoV ≤ 21%, ICC ≥ 0.75) and reliable as reflected by significant associations with left ventricular diastolic function indices assessed using both echocardiography (linear regression Pearson correlation coefficient r ≤ 0.59) and PC-MRI (r ≤ 71). Despite the fair associations between RV echocardiography and PC-MRI (r ≤ 0.25), the highest correlation with age was obtained for MRI Ef/Af ratio (r = − 0.64, p < 0.0001 vs. r = − 0.40, p = 0.0001 for echocardiographic E/A). Among PC-MRI E/A ratios, highest correlations with age were observed for flow rate and mean velocity ratios (r = − 0.61, p < 0.0001) as compared to maximal velocity ratios (r = − 0.56, p < 0.0001). Associations with age for E′ were equivalent between PC-MRI (mean velocity: r = − 0.40, p < 0.0001; maximal velocity: r = − 0.36, p = 0.0005) and echocardiography (r = − 0.36, p = 0.0006). Finally, the significant and age-independent associations between RV mass/end-diastolic volume and E′ were stronger for PC-MRI (mean velocity: r = − 0.36, p = 0.0006; maximal velocity: r = − 0.28, p = 0.007) than echocardiography (r = − 0.09, p = 0.38). PC-MRI tricuspid inflow and annulus myocardial velocity parameters were reproducible and able to characterize age-related variations in RV diastolic function. | ||
| 650 | 4 | |a Phase-contrast MRI |7 (dpeaa)DE-He213 | |
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| 650 | 4 | |a Aging |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Bollache, Emilie |e verfasserin |4 aut | |
| 700 | 1 | |a Soulat, Gilles |e verfasserin |4 aut | |
| 700 | 1 | |a Clément-Guinaudeau, Stéphanie |e verfasserin |4 aut | |
| 700 | 1 | |a Ashrafpoor, Golmehr |e verfasserin |4 aut | |
| 700 | 1 | |a Perdrix, Ludivine |e verfasserin |4 aut | |
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| 700 | 1 | |a Ladouceur, Magalie |e verfasserin |4 aut | |
| 700 | 1 | |a Mousseaux, Elie |e verfasserin |4 aut | |
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