Discrepancy between the survival rate and neuropsychological development in postsurgical extremely low-birth-weight infants: a retrospective study over two decades at a single institution
Purpose Necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI) are major diseases that cause gastrointestinal disorders in extremely low-birth-weight infants (ELBWIs). We conducted a review to compare the postoperative outcomes of ELBWIs with these diseases in our neonatal intensive-care unit. Methods A retrospective chart review of ELBWIs surgically treated for NEC (n = 31), FIP (n = 35), and MRI (n = 16) in 2001–2018 was undertaken. This period was divided into early (2001–2005), middle (2006–2010), and late (2011–2018) periods. Data were analyzed with the Cochran-Armitage test. Statistical significance was defined as p < 0.05. Results The survival rates in ELBWIs with NEC (early/middle/late: 36.4%/42.9%/61.5%; p = 0.212) and FIP (20%/50%/70.6%; p = 0.012) improved over time; all patients with MRI survived. The neuropsychological development of 24 cases was assessed with the Kyoto Scale of Psychological Development in the Postural-Motor, Cognitive-Adaptative, and Language-Social domains. The mean developmental quotient of all domains was 68.4 (range 18–95) at corrected 1.5 years of age and 69.1 (range 25–108) at chronological 3 years of age, both were considered as poor development. There was no improvement over time (p = 0.899). Conclusion Ideal neuropsychological development was not observed with the improvement of survival rate. Less-invasive surgical intervention and adequate postoperative care are required to encourage further development..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Pediatric surgery international - 37(2021), 3 vom: 11. Jan., Seite 411-417 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Muto, Mitsuru [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
Extremely low-birth-weight infants |
| doi: |
10.1007/s00383-020-04825-7 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR043268560 |
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| 245 | 1 | 0 | |a Discrepancy between the survival rate and neuropsychological development in postsurgical extremely low-birth-weight infants: a retrospective study over two decades at a single institution |
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| 520 | |a Purpose Necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI) are major diseases that cause gastrointestinal disorders in extremely low-birth-weight infants (ELBWIs). We conducted a review to compare the postoperative outcomes of ELBWIs with these diseases in our neonatal intensive-care unit. Methods A retrospective chart review of ELBWIs surgically treated for NEC (n = 31), FIP (n = 35), and MRI (n = 16) in 2001–2018 was undertaken. This period was divided into early (2001–2005), middle (2006–2010), and late (2011–2018) periods. Data were analyzed with the Cochran-Armitage test. Statistical significance was defined as p < 0.05. Results The survival rates in ELBWIs with NEC (early/middle/late: 36.4%/42.9%/61.5%; p = 0.212) and FIP (20%/50%/70.6%; p = 0.012) improved over time; all patients with MRI survived. The neuropsychological development of 24 cases was assessed with the Kyoto Scale of Psychological Development in the Postural-Motor, Cognitive-Adaptative, and Language-Social domains. The mean developmental quotient of all domains was 68.4 (range 18–95) at corrected 1.5 years of age and 69.1 (range 25–108) at chronological 3 years of age, both were considered as poor development. There was no improvement over time (p = 0.899). Conclusion Ideal neuropsychological development was not observed with the improvement of survival rate. Less-invasive surgical intervention and adequate postoperative care are required to encourage further development. | ||
| 650 | 4 | |a Extremely low-birth-weight infants |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Necrotizing enterocolitis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Focal intestinal perforation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Meconium-related ileus |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Sugita, Koshiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ibara, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Masuya, Ryuta |e verfasserin |4 aut | |
| 700 | 1 | |a Matuskubo, Makoto |e verfasserin |4 aut | |
| 700 | 1 | |a Kawano, Takafumi |e verfasserin |4 aut | |
| 700 | 1 | |a Saruwatari, Yumiko |e verfasserin |4 aut | |
| 700 | 1 | |a Machigashira, Seiro |e verfasserin |4 aut | |
| 700 | 1 | |a Sakamoto, Koichi |e verfasserin |4 aut | |
| 700 | 1 | |a Nakame, Kazuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Shinyama, Shin |e verfasserin |4 aut | |
| 700 | 1 | |a Torikai, Motofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Hayashida, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Mukai, Motoi |e verfasserin |4 aut | |
| 700 | 1 | |a Ikee, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Shimono, Ryuichi |e verfasserin |4 aut | |
| 700 | 1 | |a Noguchi, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Ieiri, Satoshi |e verfasserin |4 aut | |
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