A gendered magnifying glass on COVID-19
Abstract COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50–69 years age group, an unfavourable factor. Females are constitutionally prone to defend themselves against pathogens with a stronger efficiency than males. As a fact, several genes involved into the regulation of the innate and adaptive immune response are strategically placed on the X-chromosome and, among them, pathogen-related receptors (PRRs), such as Toll-like receptor 7, suitable to recognize ssRNAs and trigger a gendered successful anti-viral fight. On the other hand, a more regulated IL-6 production and a more contained inflammation after the encounter of a pathogen supply score points in favour of the female sex in the view that an abnormal and exaggerated cytokine release does represent the hallmark of the deathful SARS-CoV-2 infection. The sex-prevalent expression of the attachment and permissive molecules ACE2 and TMPRSS2 further supports the concept of a male-oriented vulnerability. In this review, the possible role of biological and immunological sex differences into the higher morbidity and mortality of SARS-CoV-2 between females and males are discussed..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
|---|---|
| Enthalten in: |
Clinical and molecular allergy - 18(2020), 1 vom: 04. Aug. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Salvati, Lorenzo [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.1186/s12948-020-00129-2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR040555321 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR040555321 | ||
| 003 | DE-627 | ||
| 005 | 20230520003045.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12948-020-00129-2 |2 doi | |
| 035 | |a (DE-627)SPR040555321 | ||
| 035 | |a (SPR)s12948-020-00129-2-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q ASE |
| 100 | 1 | |a Salvati, Lorenzo |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A gendered magnifying glass on COVID-19 |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50–69 years age group, an unfavourable factor. Females are constitutionally prone to defend themselves against pathogens with a stronger efficiency than males. As a fact, several genes involved into the regulation of the innate and adaptive immune response are strategically placed on the X-chromosome and, among them, pathogen-related receptors (PRRs), such as Toll-like receptor 7, suitable to recognize ssRNAs and trigger a gendered successful anti-viral fight. On the other hand, a more regulated IL-6 production and a more contained inflammation after the encounter of a pathogen supply score points in favour of the female sex in the view that an abnormal and exaggerated cytokine release does represent the hallmark of the deathful SARS-CoV-2 infection. The sex-prevalent expression of the attachment and permissive molecules ACE2 and TMPRSS2 further supports the concept of a male-oriented vulnerability. In this review, the possible role of biological and immunological sex differences into the higher morbidity and mortality of SARS-CoV-2 between females and males are discussed. | ||
| 650 | 4 | |a COVID-19 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a SARS-CoV-2 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Gender |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Sex |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Female |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a X chromosome |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a IL-6 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a TLR7 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Biagioni, Benedetta |e verfasserin |4 aut | |
| 700 | 1 | |a Vivarelli, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Parronchi, Paola |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical and molecular allergy |d London : Biomed Central, 2003 |g 18(2020), 1 vom: 04. Aug. |w (DE-627)SPR029443482 |w (DE-600)2126317-6 |x 1476-7961 |7 nnns |
| 773 | 1 | 8 | |g volume:18 |g year:2020 |g number:1 |g day:04 |g month:08 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/s12948-020-00129-2 |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 18 |j 2020 |e 1 |b 04 |c 08 | ||