Rabbit anti-thymocyte globulin (rATG) versus IL-2 receptor antagonist induction therapies in tacrolimus-based immunosuppression era: a meta-analysis
Background The aim of this meta-analysis is to explore the effect of IL-2RA vs rATG on the rate of acute rejection, post-transplant infections, and graft as well as patient’s survival in standard- and high-risk renal transplant patients receiving tacrolimus-based maintenance immunotherapy. Methods Random effects model was the method used for identifying risk difference. Confidence interval including the value 1 was used as evidence for statistically significant risk difference. Heterogeneity was assessed using Der Simonian analysis. Heterogeneity was evident at the level of P value < 0.1 Results The random effects model showed no significant differences in both acute rejection rates between IL-2RA and rATG induction therapies with relative risk of 1.24 graft survival with relative risk 0.90. Patient survival also did not demonstrate any significant difference with a relative risk of 1.19. Random effects for CMV infection showed a lesser tendency for CMV infection in IL-2RA group compared to ATG group the with a relative risk of 0.73.In subgroup analysis, the random effects model for acute rejection rates in high-risk transplants showed a higher risk of acute rejection in the IL-2RA group compared to rATG (relative risk equals 1.55) In standard-risk transplants, there were no significant differences between both groups with relative risk equals 1.02 Conclusions This meta-analysis revealed no significant difference in patient and graft survival when using IL-2RA vs rATG with the tacrolimus-based maintenance immunosuppression era. However, subgroup analysis showed less incidence of rejection in high-risk renal transplant recipient’s population using rATG compared to IL-2RA..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2020 |
---|---|
Erschienen: |
2020 |
Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
---|---|
Enthalten in: |
International urology and nephrology - 52(2020), 4 vom: 13. März, Seite 791-802 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Ali, Hatem [VerfasserIn] |
---|
Links: |
Volltext [lizenzpflichtig] |
---|
BKL: | |
---|---|
Themen: |
Calcineurin inhibitors |
doi: |
10.1007/s11255-020-02418-w |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
SPR039319962 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | SPR039319962 | ||
003 | DE-627 | ||
005 | 20230519144808.0 | ||
007 | cr uuu---uuuuu | ||
008 | 201007s2020 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s11255-020-02418-w |2 doi | |
035 | |a (DE-627)SPR039319962 | ||
035 | |a (SPR)s11255-020-02418-w-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q ASE |
084 | |a 44.88 |2 bkl | ||
100 | 1 | |a Ali, Hatem |e verfasserin |4 aut | |
245 | 1 | 0 | |a Rabbit anti-thymocyte globulin (rATG) versus IL-2 receptor antagonist induction therapies in tacrolimus-based immunosuppression era: a meta-analysis |
264 | 1 | |c 2020 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
520 | |a Background The aim of this meta-analysis is to explore the effect of IL-2RA vs rATG on the rate of acute rejection, post-transplant infections, and graft as well as patient’s survival in standard- and high-risk renal transplant patients receiving tacrolimus-based maintenance immunotherapy. Methods Random effects model was the method used for identifying risk difference. Confidence interval including the value 1 was used as evidence for statistically significant risk difference. Heterogeneity was assessed using Der Simonian analysis. Heterogeneity was evident at the level of P value < 0.1 Results The random effects model showed no significant differences in both acute rejection rates between IL-2RA and rATG induction therapies with relative risk of 1.24 graft survival with relative risk 0.90. Patient survival also did not demonstrate any significant difference with a relative risk of 1.19. Random effects for CMV infection showed a lesser tendency for CMV infection in IL-2RA group compared to ATG group the with a relative risk of 0.73.In subgroup analysis, the random effects model for acute rejection rates in high-risk transplants showed a higher risk of acute rejection in the IL-2RA group compared to rATG (relative risk equals 1.55) In standard-risk transplants, there were no significant differences between both groups with relative risk equals 1.02 Conclusions This meta-analysis revealed no significant difference in patient and graft survival when using IL-2RA vs rATG with the tacrolimus-based maintenance immunosuppression era. However, subgroup analysis showed less incidence of rejection in high-risk renal transplant recipient’s population using rATG compared to IL-2RA. | ||
650 | 4 | |a Induction therapy |7 (dpeaa)DE-He213 | |
650 | 4 | |a Renal transplant |7 (dpeaa)DE-He213 | |
650 | 4 | |a Calcineurin inhibitors |7 (dpeaa)DE-He213 | |
650 | 4 | |a Tacrolimus |7 (dpeaa)DE-He213 | |
650 | 4 | |a Outcomes |7 (dpeaa)DE-He213 | |
700 | 1 | |a Soliman, Karim M. |e verfasserin |4 aut | |
700 | 1 | |a Shaheen, Ihab |e verfasserin |4 aut | |
700 | 1 | |a Kim, Jon Jin |e verfasserin |4 aut | |
700 | 1 | |a Kossi, Mohsen El |e verfasserin |4 aut | |
700 | 1 | |a Sharma, Ajay |e verfasserin |4 aut | |
700 | 1 | |a Pararajasingam, Ravi |e verfasserin |4 aut | |
700 | 1 | |a Halawa, Ahmed |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t International urology and nephrology |d Dordrecht [u.a.] : Springer Science + Business Media B.V., 1969 |g 52(2020), 4 vom: 13. März, Seite 791-802 |w (DE-627)SPR018235247 |w (DE-600)2015547-5 |x 1573-2584 |7 nnns |
773 | 1 | 8 | |g volume:52 |g year:2020 |g number:4 |g day:13 |g month:03 |g pages:791-802 |
856 | 4 | 0 | |u https://dx.doi.org/10.1007/s11255-020-02418-w |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_SPRINGER | ||
912 | |a SSG-OLC-PHA | ||
936 | b | k | |a 44.88 |q ASE |
951 | |a AR | ||
952 | |d 52 |j 2020 |e 4 |b 13 |c 03 |h 791-802 |