Hepatic sinusoidal obstruction syndrome secondary to intravesical instillation of mitomycin-C
Abstract Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening complication with high mortality rate. Even if it is more commonly described after hematopoietic stem-cell transplant, hepatic-SOS may occur following the use of certain chemotherapeutic agents. Mitomycin-C has been previously identified as a causal agent when administered intravenously at high doses. We report herein the first case of hepatic-SOS due to intravesical instillation of mitomycin-C, after a traumatic urinary catheterization with significant hematuria. Although this procedure is usually considered safe, without the systemic side effects related to intravenous administration of the drug, clinicians must be aware of its potential risks to facilitate an early diagnosis, avoid a delay in the withdrawal of the causative drug and set up an appropriate therapy as soon as possible..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Clinical journal of gastroenterology - 13(2019), 2 vom: 16. Sept., Seite 271-275 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Marchán-López, Álvaro [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
Bone marrow aplasia |
| doi: |
10.1007/s12328-019-01042-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR039229092 |
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| 520 | |a Abstract Hepatic sinusoidal obstruction syndrome (SOS) is a life-threatening complication with high mortality rate. Even if it is more commonly described after hematopoietic stem-cell transplant, hepatic-SOS may occur following the use of certain chemotherapeutic agents. Mitomycin-C has been previously identified as a causal agent when administered intravenously at high doses. We report herein the first case of hepatic-SOS due to intravesical instillation of mitomycin-C, after a traumatic urinary catheterization with significant hematuria. Although this procedure is usually considered safe, without the systemic side effects related to intravenous administration of the drug, clinicians must be aware of its potential risks to facilitate an early diagnosis, avoid a delay in the withdrawal of the causative drug and set up an appropriate therapy as soon as possible. | ||
| 650 | 4 | |a Intravesical instillation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Mitomycin-C |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Bone marrow aplasia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Hepatic sinusoidal obstruction syndrome |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Pérez-Jacoiste Asín, María Asunción |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez-Almonacid, Justino |e verfasserin |4 aut | |
| 700 | 1 | |a Arroyo-López, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Justo-Quintas, Juan |e verfasserin |4 aut | |
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