Effects of prolonged direct hemoperfusion using a polymyxin B immobilized fiber cartridge on interleukin-6 concentration in patients with septic shock: a prospective exploratory trial
Background The aim of this study was to evaluate the effect of prolonged direct hemoperfusion using polymyxin B immobilized fiber cartridges (PMX-DHP) on interleukin-6 (IL-6) concentration in patients with septic shock. Methods A total of 16 patients received a total of 26 sessions of 12-h PMX-DHP (PMX-DHP-12h group) and 7 patients received a total of 11 sessions of 2-h PMX-DHP (PMX-DHP-2h group). We compared serum IL-6 concentrations and other secondary outcomes between the two treatment groups. IL-6 concentrations were measured at 0, 2, 5, 8, and 12 h. Results The median age was 78 years (interquartile range [IQR] 60–84) in PMX-DHP-12h group and 75 years (IQR 66–81) in PMX-DHP-2h group (P = 0.92). The median acute physiology and chronic health evaluation II score was 23 (IQR 18–31) in the PMX-DHP-12h group and 21 (IQR 17–28) in the PMX-DHP-2h group (P = 0.64). A major source of infection in both groups was the abdomen. The serum IL-6 concentrations in both groups significantly decreased at each time point after 0 h (P < 0.05). However, the decrease in IL-6 concentration did not differ between the groups (P = 0.92). In-hospital mortality was not significantly different in the PMX-DHP-12h group vs. PMX-DHP-2h group (7 patients [44%] vs. 1 patient [14%]; P = 0.35). Conclusions We could not confirm the additional effect that 12 h of PMX-DHP had on the reduction in serum IL-6 concentrations over that exerted by 2 h of this regimen. Trial registration UMIN-CTR, UMIN000016654. Registered 3 March 2015.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2019 |
|---|---|
| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
Renal replacement therapy - 5(2019), 1 vom: 14. Mai |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Miyamoto, Kyohei [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| Anmerkungen: |
© The Author(s) 2019 |
|---|
| doi: |
10.1186/s41100-019-0217-8 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR038268426 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR038268426 | ||
| 003 | DE-627 | ||
| 005 | 20230519195550.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s41100-019-0217-8 |2 doi | |
| 035 | |a (DE-627)SPR038268426 | ||
| 035 | |a (SPR)s41100-019-0217-8-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Miyamoto, Kyohei |e verfasserin |0 (orcid)0000-0001-5473-2731 |4 aut | |
| 245 | 1 | 0 | |a Effects of prolonged direct hemoperfusion using a polymyxin B immobilized fiber cartridge on interleukin-6 concentration in patients with septic shock: a prospective exploratory trial |
| 264 | 1 | |c 2019 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) 2019 | ||
| 520 | |a Background The aim of this study was to evaluate the effect of prolonged direct hemoperfusion using polymyxin B immobilized fiber cartridges (PMX-DHP) on interleukin-6 (IL-6) concentration in patients with septic shock. Methods A total of 16 patients received a total of 26 sessions of 12-h PMX-DHP (PMX-DHP-12h group) and 7 patients received a total of 11 sessions of 2-h PMX-DHP (PMX-DHP-2h group). We compared serum IL-6 concentrations and other secondary outcomes between the two treatment groups. IL-6 concentrations were measured at 0, 2, 5, 8, and 12 h. Results The median age was 78 years (interquartile range [IQR] 60–84) in PMX-DHP-12h group and 75 years (IQR 66–81) in PMX-DHP-2h group (P = 0.92). The median acute physiology and chronic health evaluation II score was 23 (IQR 18–31) in the PMX-DHP-12h group and 21 (IQR 17–28) in the PMX-DHP-2h group (P = 0.64). A major source of infection in both groups was the abdomen. The serum IL-6 concentrations in both groups significantly decreased at each time point after 0 h (P < 0.05). However, the decrease in IL-6 concentration did not differ between the groups (P = 0.92). In-hospital mortality was not significantly different in the PMX-DHP-12h group vs. PMX-DHP-2h group (7 patients [44%] vs. 1 patient [14%]; P = 0.35). Conclusions We could not confirm the additional effect that 12 h of PMX-DHP had on the reduction in serum IL-6 concentrations over that exerted by 2 h of this regimen. Trial registration UMIN-CTR, UMIN000016654. Registered 3 March 2015 | ||
| 650 | 4 | |a Interleukin-6 |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PMX-DHP |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Septic shock |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Kawazoe, Yu |4 aut | |
| 700 | 1 | |a Negi, Shigeo |4 aut | |
| 700 | 1 | |a Shibata, Naoaki |4 aut | |
| 700 | 1 | |a Ogawa, Atsuhiro |4 aut | |
| 700 | 1 | |a Shima, Nozomu |4 aut | |
| 700 | 1 | |a Kunitatsu, Kosei |4 aut | |
| 700 | 1 | |a Shima, Yukihiro |4 aut | |
| 700 | 1 | |a Yamamoto, Nobuko |4 aut | |
| 700 | 1 | |a Kaneko, Masahiro |4 aut | |
| 700 | 1 | |a Kida, Maki |4 aut | |
| 700 | 1 | |a Tanaka, Masaou |4 aut | |
| 700 | 1 | |a Ohya, Masaki |4 aut | |
| 700 | 1 | |a Shigematsu, Takashi |4 aut | |
| 700 | 1 | |a Kato, Seiya |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Renal replacement therapy |d [London] : BioMed Central, 2015 |g 5(2019), 1 vom: 14. Mai |w (DE-627)SPR038245647 |w (DE-600)2866852-2 |x 2059-1381 |7 nnns |
| 773 | 1 | 8 | |g volume:5 |g year:2019 |g number:1 |g day:14 |g month:05 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/s41100-019-0217-8 |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 5 |j 2019 |e 1 |b 14 |c 05 | ||