Adoptive T Regulatory Cell Therapy for Tolerance Induction
Abstract There is a clear need to develop strategies to induce tolerance without the need of chronic immunosuppression in transplant recipient and in patients with autoimmunity. Adoptive T regulatory cell ($ T_{reg} $) therapy offers the potential of long-lasting protection. However, based on results of clinical trials so far with ex vivo expanded autologous $ T_{regs} $ in type 1 diabetic (T1D) patients, it seems unlikely that single immunotherapy with $ T_{reg} $ infusion without immunomodulation regimens that promote stable donor $ T_{reg} $ engraftment and persistence would afford truly significant clinical benefit. Combination therapies could provide improved outcomes with consideration of the fundamental factors required for $ T_{reg} $ generation, homeostasis, and function to promote long-term donor $ T_{reg} $ persistence to provoke beneficial therapeutic outcomes..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
Current transplantation reports - 2(2015), 2 vom: 02. Apr., Seite 191-201 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cabello-Kindelan, Cecilia [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
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| Anmerkungen: |
© Springer International Publishing AG 2015 |
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| doi: |
10.1007/s40472-015-0058-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR036493856 |
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| 520 | |a Abstract There is a clear need to develop strategies to induce tolerance without the need of chronic immunosuppression in transplant recipient and in patients with autoimmunity. Adoptive T regulatory cell ($ T_{reg} $) therapy offers the potential of long-lasting protection. However, based on results of clinical trials so far with ex vivo expanded autologous $ T_{regs} $ in type 1 diabetic (T1D) patients, it seems unlikely that single immunotherapy with $ T_{reg} $ infusion without immunomodulation regimens that promote stable donor $ T_{reg} $ engraftment and persistence would afford truly significant clinical benefit. Combination therapies could provide improved outcomes with consideration of the fundamental factors required for $ T_{reg} $ generation, homeostasis, and function to promote long-term donor $ T_{reg} $ persistence to provoke beneficial therapeutic outcomes. | ||
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