Cardiovascular Disease Risk in Living Kidney Donors: Knowns and Unknowns
Purpose of Review This review aimed to summarize evidence regarding mid- and long-term cardiovascular risks associated with living kidney donation in adults. Recent Findings Chronic kidney disease is a major risk factor for cardiovascular disease. It is known that glomerular filtration rate declines among many donors after donation; as a result, these donors can be classified as having early stage chronic kidney disease. Even though initial reports suggested no increase in adverse cardiovascular effects compared with control populations, recent data have shown a possible late increase in cardiovascular event rates and small structural and functional cardiovascular abnormalities. The long-term significance of these abnormalities is unknown. Summary It is not possible to draw strong conclusions on whether the reduction in glomerular filtration rate caused by kidney donation causes an increase in adverse cardiovascular events. Further prospective studies are needed to evaluate the natural history of cardiac and vascular structural and functional abnormalities and their clinical significance..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Current epidemiology reports - 7(2020), 1 vom: 14. Jan., Seite 44-48 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ari, Elif [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
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| Anmerkungen: |
© Springer Nature Switzerland AG 2020 |
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| doi: |
10.1007/s40471-020-00223-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
SPR036493147 |
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| 520 | |a Purpose of Review This review aimed to summarize evidence regarding mid- and long-term cardiovascular risks associated with living kidney donation in adults. Recent Findings Chronic kidney disease is a major risk factor for cardiovascular disease. It is known that glomerular filtration rate declines among many donors after donation; as a result, these donors can be classified as having early stage chronic kidney disease. Even though initial reports suggested no increase in adverse cardiovascular effects compared with control populations, recent data have shown a possible late increase in cardiovascular event rates and small structural and functional cardiovascular abnormalities. The long-term significance of these abnormalities is unknown. Summary It is not possible to draw strong conclusions on whether the reduction in glomerular filtration rate caused by kidney donation causes an increase in adverse cardiovascular events. Further prospective studies are needed to evaluate the natural history of cardiac and vascular structural and functional abnormalities and their clinical significance. | ||
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