Predictors of Malnutrition in Children with Cystic Fibrosis
Objective To determine occurrence of malnutrition in children with cystic fibrosis and identify predictors of malnutrition at time of enrolment and after 2 years of follow up. Design Retrospective chart review. Setting Pediatric chest clinic at a tertiary-care center in northern India. Patients Cystic fibrosis patients enrolled between 2009–2015 with at least 3 years follow-up. Procedure Weight and height were noted at enrolment, and after 1 year and 2 years of follow-up. Clinical details, medications, and pulmonary exacerbations during second year were recorded. Main outcome measure Occurrence of malnutrition i.e. weight for age Z-score < −2. Results 61 medical records were reviewed. Occurrence of malnutrition at baseline, and 1- and 2-year follow-up was 65.5%, 54.1% and 57.3%, respectively. Weight for age Z-score at enrolment significantly correlated with time to diagnosis from onset r=0.015, P=0.029). Weight for age Z-score at 2-year follow-up was significantly associated with steatorrhea (P=0.03), increased frequency of stools (P<0.01) and pulmonary exacerbation (P=0.03) during second year. Linear regression showed significant association between weight for age Z-score at 2 years with steatorrhea and pulmonary exacerbations [r=−10.795 (−1.527, −0.062)] and [r=−0.261 (−0.493, −0.028)]. Pulmonary exacerbations during second and third year had significant correlation with weight for age Z-score at the beginning of respective years (r = −0.219, P=0.015). Conclusion Occurrence of malnutrition is high in children with cystic fibrosis in this region, with uncontrolled fat malabsorption and recurrent respiratory infections being significant risk factors..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2019 |
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| Erschienen: |
2019 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Indian Pediatrics - 56(2019), 10 vom: 10. Aug., Seite 825-830 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dhochak, Nitin [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
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| Anmerkungen: |
© Indian Academy of Pediatrics 2019 |
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| doi: |
10.1007/s13312-019-1607-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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SPR031297447 |
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| 520 | |a Objective To determine occurrence of malnutrition in children with cystic fibrosis and identify predictors of malnutrition at time of enrolment and after 2 years of follow up. Design Retrospective chart review. Setting Pediatric chest clinic at a tertiary-care center in northern India. Patients Cystic fibrosis patients enrolled between 2009–2015 with at least 3 years follow-up. Procedure Weight and height were noted at enrolment, and after 1 year and 2 years of follow-up. Clinical details, medications, and pulmonary exacerbations during second year were recorded. Main outcome measure Occurrence of malnutrition i.e. weight for age Z-score < −2. Results 61 medical records were reviewed. Occurrence of malnutrition at baseline, and 1- and 2-year follow-up was 65.5%, 54.1% and 57.3%, respectively. Weight for age Z-score at enrolment significantly correlated with time to diagnosis from onset r=0.015, P=0.029). Weight for age Z-score at 2-year follow-up was significantly associated with steatorrhea (P=0.03), increased frequency of stools (P<0.01) and pulmonary exacerbation (P=0.03) during second year. Linear regression showed significant association between weight for age Z-score at 2 years with steatorrhea and pulmonary exacerbations [r=−10.795 (−1.527, −0.062)] and [r=−0.261 (−0.493, −0.028)]. Pulmonary exacerbations during second and third year had significant correlation with weight for age Z-score at the beginning of respective years (r = −0.219, P=0.015). Conclusion Occurrence of malnutrition is high in children with cystic fibrosis in this region, with uncontrolled fat malabsorption and recurrent respiratory infections being significant risk factors. | ||
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| 700 | 1 | |a Kabra, Sushil K. |4 aut | |
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