Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk
Background Epidemiological studies of the association between nonsteroidal anti-inflammatory drug (NSAID) intake and the risk of prostate cancer still remain controversial. Therefore, we conducted a meta-analysis to evaluate the potential association between NSAID intake and prostate cancer risk. Methods Eligible studies were retrieved by both computerized searches and reviews of references. Subgroup analyses on country and design of study were also performed. Random or fixed-effect models were used to pool estimates of odds ratios (ORs) with 95% confidence intervals (CIs). Results We observed that the intake of aspirin was associated with a marginally decreased risk of prostate cancer (OR =0.95, 95% CI =0.93 to 0.98). A similar result was found between nonaspirin NSAIDs and prostate cancer risk (OR =0.94, 95% CI =0.90 to 0.98). However, a positive relation between all-NSAID intake and prostate cancer risk was observed (OR =1.18, 95% CI =1.15 to 1.22). Conclusions We observed a marginally inverse correlation between the intake of aspirin and prostate cancer risk. On the contrary, a positive relationship between all-NSAID intake and prostate cancer was detected. Further research needs to be conducted to better clarify potential biological mechanisms..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
World journal of surgical oncology - 12(2014), 1 vom: 05. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Xiao [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| Anmerkungen: |
© Wang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( |
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| doi: |
10.1186/1477-7819-12-304 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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SPR028828070 |
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| 500 | |a © Wang et al.; licensee BioMed Central Ltd. 2014. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( | ||
| 520 | |a Background Epidemiological studies of the association between nonsteroidal anti-inflammatory drug (NSAID) intake and the risk of prostate cancer still remain controversial. Therefore, we conducted a meta-analysis to evaluate the potential association between NSAID intake and prostate cancer risk. Methods Eligible studies were retrieved by both computerized searches and reviews of references. Subgroup analyses on country and design of study were also performed. Random or fixed-effect models were used to pool estimates of odds ratios (ORs) with 95% confidence intervals (CIs). Results We observed that the intake of aspirin was associated with a marginally decreased risk of prostate cancer (OR =0.95, 95% CI =0.93 to 0.98). A similar result was found between nonaspirin NSAIDs and prostate cancer risk (OR =0.94, 95% CI =0.90 to 0.98). However, a positive relation between all-NSAID intake and prostate cancer risk was observed (OR =1.18, 95% CI =1.15 to 1.22). Conclusions We observed a marginally inverse correlation between the intake of aspirin and prostate cancer risk. On the contrary, a positive relationship between all-NSAID intake and prostate cancer was detected. Further research needs to be conducted to better clarify potential biological mechanisms. | ||
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| 650 | 4 | |a Prostate cancer |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Lin, Yi-wei |4 aut | |
| 700 | 1 | |a Wu, Jian |4 aut | |
| 700 | 1 | |a Zhu, Yi |4 aut | |
| 700 | 1 | |a Xu, Xiang-lai |4 aut | |
| 700 | 1 | |a Xu, Xin |4 aut | |
| 700 | 1 | |a Liang, Zhen |4 aut | |
| 700 | 1 | |a Hu, Zheng-hui |4 aut | |
| 700 | 1 | |a Li, Shi-qi |4 aut | |
| 700 | 1 | |a Zheng, Xiang-yi |4 aut | |
| 700 | 1 | |a Xie, Li-ping |4 aut | |
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