Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study
Background Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and $ FEV_{1} $-decline in male heavy smokers. Methods 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and $ FEV_{1} $-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference. Results Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 – 14.1) and mean (SD) $ FEV_{1} $ was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted ‘>5 years’ showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly $ FEV_{1} $-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001). Conclusion Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline. Trial registration Registered at http://www.trialregister.nl with trial number ISRCTN63545820..
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2013 |
---|---|
Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
---|---|
Enthalten in: |
Respiratory research - 14(2013), 1 vom: 20. Mai |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mohamed Hoesein, Firdaus AA [VerfasserIn] |
---|
Links: |
Volltext [kostenfrei] |
---|
Themen: |
Chronic obstructive pulmonary disease (COPD) |
---|
Anmerkungen: |
© Mohamed Hoesein et al.; licensee BioMed Central Ltd. 2013 |
---|
doi: |
10.1186/1465-9921-14-55 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
SPR028515730 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | SPR028515730 | ||
003 | DE-627 | ||
005 | 20230519212224.0 | ||
007 | cr uuu---uuuuu | ||
008 | 201007s2013 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1186/1465-9921-14-55 |2 doi | |
035 | |a (DE-627)SPR028515730 | ||
035 | |a (SPR)1465-9921-14-55-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Mohamed Hoesein, Firdaus AA |e verfasserin |4 aut | |
245 | 1 | 0 | |a Rate of progression of CT-quantified emphysema in male current and ex-smokers: a follow-up study |
264 | 1 | |c 2013 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a © Mohamed Hoesein et al.; licensee BioMed Central Ltd. 2013 | ||
520 | |a Background Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / demographical factors on the rate of emphysema progression and $ FEV_{1} $-decline in male heavy smokers. Methods 3,670 male smokers with mean (SD) 40.8 (17.9) packyears underwent chest CT scans and pulmonary function tests at baseline and after 1 and 3 years follow-up. Smoking status (quitted ≥5, ≥1-<5, <1 years or current smoker) was noted. Rate of progression of emphysema and $ FEV_{1} $-decline after follow-up were assessed by analysis of variance adjusting for age, height, baseline pulmonary function and emphysema severity, packyears, years in study and respiratory symptoms. The quitted ≥5 group was used as reference. Results Median (Q1-Q3) emphysema severity,<-950 HU, was 8.8 (5.1 – 14.1) and mean (SD) $ FEV_{1} $ was 3.4 (0.73) L or 98.5 (18.5) % of predicted. The group quitted ‘>5 years’ showed significantly lower rates of progression of emphysema compared to current smokers, 1.07% and 1.12% per year, respectively (p<0.001). Current smokers had a yearly $ FEV_{1} $-decline of 69 ml, while subjects quit smoking >5 years had a yearly decline of 57.5 ml (p<0.001). Conclusion Quit smoking >5 years significantly slows the rate of emphysema progression and lung function decline. Trial registration Registered at http://www.trialregister.nl with trial number ISRCTN63545820. | ||
650 | 4 | |a Chronic obstructive pulmonary disease (COPD) |7 (dpeaa)DE-He213 | |
650 | 4 | |a Emphysema |7 (dpeaa)DE-He213 | |
650 | 4 | |a Smoking |7 (dpeaa)DE-He213 | |
650 | 4 | |a Pulmonary function testing |7 (dpeaa)DE-He213 | |
700 | 1 | |a Zanen, Pieter |4 aut | |
700 | 1 | |a de Jong, Pim A |4 aut | |
700 | 1 | |a van Ginneken, Bram |4 aut | |
700 | 1 | |a Boezen, H Marike |4 aut | |
700 | 1 | |a Groen, Harry JM |4 aut | |
700 | 1 | |a Oudkerk, Mathijs |4 aut | |
700 | 1 | |a de Koning, Harry J |4 aut | |
700 | 1 | |a Postma, Dirkje S |4 aut | |
700 | 1 | |a Lammers, Jan-Willem J |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Respiratory research |d London : BioMed Central, 2001 |g 14(2013), 1 vom: 20. Mai |w (DE-627)SPR028499905 |w (DE-600)2041675-1 |x 1465-993X |7 nnns |
773 | 1 | 8 | |g volume:14 |g year:2013 |g number:1 |g day:20 |g month:05 |
856 | 4 | 0 | |u https://dx.doi.org/10.1186/1465-9921-14-55 |z kostenfrei |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_SPRINGER | ||
912 | |a SSG-OLC-PHA | ||
951 | |a AR | ||
952 | |d 14 |j 2013 |e 1 |b 20 |c 05 |