Fast myocardial perfusion imaging with 99mTc in challenging patients using conventional SPECT cameras
Background We attempted to validate the performance of a fast myocardial perfusion imaging (MPI) protocol in diagnostically challenging patients. Methods 78 patients with ΒΜΙ > 24.9, LVH or three vessels disease underwent two sequential gated-MPI studies. The first at 15 (Early Imaging, EI) and the second at 45 (Late Imaging, LI) minutes post 99mTc-injection, at both stress and rest. Counts over heart (H), liver (Liv) and subdiaphragmatic space (Sub) and image quality, and myocardial perfusion and function parameters were compared between the two protocols. Coronary angiography was performed within 2 months from MPI, and ROC analysis was used to compare the diagnostic accuracy for the detection of ≥50% diameter luminal stenosis. Results Quality was optimal-good in 93% of EI and 98% of LI studies (P = .12), H/Liv and stress H/Sub ratios were similar, but rest H/Sub ratio was lower in EI (P = .009). SSS [10 (0 to 46) vs 9 (0 to 36), P = .006] and SDS [3 (0 to 35) vs 2 (0 to 34), P = .02] were higher in EI protocol. LVEF, motion and thickening scores did not differ between the two protocols. A highly significant (P < .001) linear relationship with clinically negligible mean differences in Bland-Altman analysis was observed for all perfusion and function-related data. Sensitivity (EI 81%, LI 80%) and specificity (65% for both) did not differ (P = .23) between the two protocols. Conclusion The fast protocol is technically feasible and diagnostically accurate compared to the established protocol in diagnostically challenging patients..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2016 |
|---|---|
| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
|---|---|
| Enthalten in: |
Journal of nuclear cardiology - 24(2016), 4 vom: 14. März, Seite 1314-1327 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Katsikis, Athanasios [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| Themen: |
Diagnostically challenging patients |
|---|
| Anmerkungen: |
© American Society of Nuclear Cardiology 2016 |
|---|
| doi: |
10.1007/s12350-016-0431-5 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR024984000 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR024984000 | ||
| 003 | DE-627 | ||
| 005 | 20230519143450.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201007s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12350-016-0431-5 |2 doi | |
| 035 | |a (DE-627)SPR024984000 | ||
| 035 | |a (SPR)s12350-016-0431-5-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Katsikis, Athanasios |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Fast myocardial perfusion imaging with 99mTc in challenging patients using conventional SPECT cameras |
| 264 | 1 | |c 2016 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © American Society of Nuclear Cardiology 2016 | ||
| 520 | |a Background We attempted to validate the performance of a fast myocardial perfusion imaging (MPI) protocol in diagnostically challenging patients. Methods 78 patients with ΒΜΙ > 24.9, LVH or three vessels disease underwent two sequential gated-MPI studies. The first at 15 (Early Imaging, EI) and the second at 45 (Late Imaging, LI) minutes post 99mTc-injection, at both stress and rest. Counts over heart (H), liver (Liv) and subdiaphragmatic space (Sub) and image quality, and myocardial perfusion and function parameters were compared between the two protocols. Coronary angiography was performed within 2 months from MPI, and ROC analysis was used to compare the diagnostic accuracy for the detection of ≥50% diameter luminal stenosis. Results Quality was optimal-good in 93% of EI and 98% of LI studies (P = .12), H/Liv and stress H/Sub ratios were similar, but rest H/Sub ratio was lower in EI (P = .009). SSS [10 (0 to 46) vs 9 (0 to 36), P = .006] and SDS [3 (0 to 35) vs 2 (0 to 34), P = .02] were higher in EI protocol. LVEF, motion and thickening scores did not differ between the two protocols. A highly significant (P < .001) linear relationship with clinically negligible mean differences in Bland-Altman analysis was observed for all perfusion and function-related data. Sensitivity (EI 81%, LI 80%) and specificity (65% for both) did not differ (P = .23) between the two protocols. Conclusion The fast protocol is technically feasible and diagnostically accurate compared to the established protocol in diagnostically challenging patients. | ||
| 650 | 4 | |a Myocardial perfusion imaging |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a fast protocol |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a tetrofosmin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a diagnostically challenging patients |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Theodorakos, Athanasios |4 aut | |
| 700 | 1 | |a Kouzoumi, Anna |4 aut | |
| 700 | 1 | |a Kitziri, Elpida |4 aut | |
| 700 | 1 | |a Georgiou, Evangelos |4 aut | |
| 700 | 1 | |a Koutelou, Maria |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of nuclear cardiology |d New York, NY : Springer, 1994 |g 24(2016), 4 vom: 14. März, Seite 1314-1327 |w (DE-627)SPR024965006 |w (DE-600)2048325-9 |x 1532-6551 |7 nnns |
| 773 | 1 | 8 | |g volume:24 |g year:2016 |g number:4 |g day:14 |g month:03 |g pages:1314-1327 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s12350-016-0431-5 |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |d 24 |j 2016 |e 4 |b 14 |c 03 |h 1314-1327 | ||