T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production
Abstract Besides the classically described subsets of memory CD8 T cells generated under infectious conditions, are T inflammatory memory cells generated under sterile priming conditions, such as sensitization to allergens. Although not fully differentiated as pathogen-induced memory cells, they display memory properties that distinguish them from naive CD8 T cells. Given these memory cells are generated in an antigen-specific context that is devoid of pathogen-derived danger signals and CD4 T cell help, we herein questioned whether they maintained their activation and differentiation potential, could be recruited in an immune response directed against a pathogen expressing their cognate antigen and further differentiate in fully competent secondary memory cells. We show that T inflammatory memory cells can indeed take part to the immune response triggered by a viral infection, differentiate into secondary effectors and further generate typical central memory CD8 T cells and effector memory CD8 T cells. Furthermore, the secondary memory cells they generate display a functional advantage over primary memory cells in their capacity to produce TNF-α and the XCL1 chemokine. These results suggest that cross-reactive stimulations and differentiation of cells directed against allergens or self into fully competent pathogen-induced memory cells might have incidences in inflammatory immuno-pathologies..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:52 |
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| Enthalten in: |
Immunologic research - 52(2012), 3 vom: 19. Apr., Seite 284-293 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jubin, Virginie [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
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| Anmerkungen: |
© Springer Science+Business Media, LLC 2012 |
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| doi: |
10.1007/s12026-012-8340-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Abstract Besides the classically described subsets of memory CD8 T cells generated under infectious conditions, are T inflammatory memory cells generated under sterile priming conditions, such as sensitization to allergens. Although not fully differentiated as pathogen-induced memory cells, they display memory properties that distinguish them from naive CD8 T cells. Given these memory cells are generated in an antigen-specific context that is devoid of pathogen-derived danger signals and CD4 T cell help, we herein questioned whether they maintained their activation and differentiation potential, could be recruited in an immune response directed against a pathogen expressing their cognate antigen and further differentiate in fully competent secondary memory cells. We show that T inflammatory memory cells can indeed take part to the immune response triggered by a viral infection, differentiate into secondary effectors and further generate typical central memory CD8 T cells and effector memory CD8 T cells. Furthermore, the secondary memory cells they generate display a functional advantage over primary memory cells in their capacity to produce TNF-α and the XCL1 chemokine. These results suggest that cross-reactive stimulations and differentiation of cells directed against allergens or self into fully competent pathogen-induced memory cells might have incidences in inflammatory immuno-pathologies. | ||
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| 650 | 4 | |a Antiviral response |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a XCL1 |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Ventre, Erwan |4 aut | |
| 700 | 1 | |a Leverrier, Yann |4 aut | |
| 700 | 1 | |a Djebali, Sophia |4 aut | |
| 700 | 1 | |a Mayol, Katia |4 aut | |
| 700 | 1 | |a Tomkowiak, Martine |4 aut | |
| 700 | 1 | |a Mafille, Julien |4 aut | |
| 700 | 1 | |a Teixeira, Marie |4 aut | |
| 700 | 1 | |a Teoh, Denise Y.-L. |4 aut | |
| 700 | 1 | |a Lina, Bruno |4 aut | |
| 700 | 1 | |a Walzer, Thierry |4 aut | |
| 700 | 1 | |a Arpin, Christophe |4 aut | |
| 700 | 1 | |a Marvel, Jacqueline |4 aut | |
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