Staphylococcus aureus genomic pattern and atopic dermatitis: may factors other than superantigens be involved?
Abstract The purpose of this investigation was to compare the genotypic profiles of Staphylococcus aureus isolated from atopic dermatitis (AD) patients and from control subjects, and to study the relationship between clinical severity, immune response, and genomic pattern of S. aureus isolated from AD patients. We selected 32 patients with AD and S. aureus skin colonization and 31 atopic controls with no history of AD who where asymptomatic carriers of S. aureus. Microarray-based genotyping was performed on S. aureus isolates. In AD patients, clinical severity was assessed using the Scoring Atopic Dermatitis index and total IgE levels and staphylococcal superantigen-specific IgE levels (SEA, SEB, SEC, TSST1) were determined. The genes lukE, lukD, splA, splB, ssl8, and sasG were more frequent in isolates from AD patients. CC30 was more common in isolates from atopic controls than in AD patients. There was a correlation between total IgE and clinical severity, but an association between clinical severity, immune response, and the presence of S. aureus superantigen genes, including enterotoxin genes, could not be demonstrated. Finally, a correlation was found between AD severity and other S. aureus genes, such as sasG and scn. S. aureus factors besides superantigens could be related to the worsening and onset of AD..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
|---|---|
| Enthalten in: |
European journal of clinical microbiology & infectious diseases - 33(2013), 4 vom: 27. Okt., Seite 651-658 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rojo, A. [VerfasserIn] |
|---|
| Links: |
Volltext [lizenzpflichtig] |
|---|
| BKL: | |
|---|---|
| Themen: |
Adherence Factor |
| doi: |
10.1007/s10096-013-2000-z |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
SPR008693137 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR008693137 | ||
| 003 | DE-627 | ||
| 005 | 20230519214219.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201005s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10096-013-2000-z |2 doi | |
| 035 | |a (DE-627)SPR008693137 | ||
| 035 | |a (SPR)s10096-013-2000-z-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 610 |q ASE |
| 084 | |a 44.43 |2 bkl | ||
| 084 | |a 44.75 |2 bkl | ||
| 100 | 1 | |a Rojo, A. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Staphylococcus aureus genomic pattern and atopic dermatitis: may factors other than superantigens be involved? |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract The purpose of this investigation was to compare the genotypic profiles of Staphylococcus aureus isolated from atopic dermatitis (AD) patients and from control subjects, and to study the relationship between clinical severity, immune response, and genomic pattern of S. aureus isolated from AD patients. We selected 32 patients with AD and S. aureus skin colonization and 31 atopic controls with no history of AD who where asymptomatic carriers of S. aureus. Microarray-based genotyping was performed on S. aureus isolates. In AD patients, clinical severity was assessed using the Scoring Atopic Dermatitis index and total IgE levels and staphylococcal superantigen-specific IgE levels (SEA, SEB, SEC, TSST1) were determined. The genes lukE, lukD, splA, splB, ssl8, and sasG were more frequent in isolates from AD patients. CC30 was more common in isolates from atopic controls than in AD patients. There was a correlation between total IgE and clinical severity, but an association between clinical severity, immune response, and the presence of S. aureus superantigen genes, including enterotoxin genes, could not be demonstrated. Finally, a correlation was found between AD severity and other S. aureus genes, such as sasG and scn. S. aureus factors besides superantigens could be related to the worsening and onset of AD. | ||
| 650 | 4 | |a Atopic Dermatitis |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Clonal Complex |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Atopic Dermatitis Patient |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Atopic Dermatitis Severity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Adherence Factor |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Aguinaga, A. |e verfasserin |4 aut | |
| 700 | 1 | |a Monecke, S. |e verfasserin |4 aut | |
| 700 | 1 | |a Yuste, J. R. |e verfasserin |4 aut | |
| 700 | 1 | |a Gastaminza, G. |e verfasserin |4 aut | |
| 700 | 1 | |a España, A. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of clinical microbiology & infectious diseases |d Berlin : Springer, 1982 |g 33(2013), 4 vom: 27. Okt., Seite 651-658 |w (DE-627)SPR008661995 |w (DE-600)1459049-9 |x 1435-4373 |7 nnns |
| 773 | 1 | 8 | |g volume:33 |g year:2013 |g number:4 |g day:27 |g month:10 |g pages:651-658 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/s10096-013-2000-z |z lizenzpflichtig |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 44.43 |q ASE |
| 936 | b | k | |a 44.75 |q ASE |
| 951 | |a AR | ||
| 952 | |d 33 |j 2013 |e 4 |b 27 |c 10 |h 651-658 | ||