Organizing pneumonia and occupational and environmental risk factors: a case–control study
Objectives A single-center case–control study was carried out to investigate the relationship between occupational and environmental exposure and organizing pneumonia (OP). Methods Thirty-seven cases of OP, including 25 cases of cryptogenic OP, and 111 controls were included. Occupational exposure was assessed retrospectively by an industrial hygienist and an occupational physician, through semi-quantitative estimates of exposure. An exposure score was calculated for each subject, based on probability, intensity, daily frequency, and duration of exposure for each period of employment. The final cumulative exposure score was obtained by summing exposure scores for all periods of employment. Results Significant associations with all-cause OP were observed for exposure to tetrachloroethylene (OR 13.33, CI 95% 1.44–123.5) and silica (OR 6.61, CI 95% 1.16–37.71). A significant association with cryptogenic OP was observed only for tetrachloroethylene (OR 31.6, CI 95% 1.64–610.8). No associations were found for environmental exposure. Conclusion Despite its low statistical power, this work suggests that occupational risk factors could be involved in OP..
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:90 |
|---|---|
| Enthalten in: |
International archives of occupational and environmental health - 90(2017), 8 vom: 01. Aug., Seite 865-871 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jobard, Stéphanie [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| BKL: | |
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| Themen: |
Cryptogenic organizing pneumonia |
| doi: |
10.1007/s00420-017-1249-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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SPR005498732 |
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| 520 | |a Objectives A single-center case–control study was carried out to investigate the relationship between occupational and environmental exposure and organizing pneumonia (OP). Methods Thirty-seven cases of OP, including 25 cases of cryptogenic OP, and 111 controls were included. Occupational exposure was assessed retrospectively by an industrial hygienist and an occupational physician, through semi-quantitative estimates of exposure. An exposure score was calculated for each subject, based on probability, intensity, daily frequency, and duration of exposure for each period of employment. The final cumulative exposure score was obtained by summing exposure scores for all periods of employment. Results Significant associations with all-cause OP were observed for exposure to tetrachloroethylene (OR 13.33, CI 95% 1.44–123.5) and silica (OR 6.61, CI 95% 1.16–37.71). A significant association with cryptogenic OP was observed only for tetrachloroethylene (OR 31.6, CI 95% 1.64–610.8). No associations were found for environmental exposure. Conclusion Despite its low statistical power, this work suggests that occupational risk factors could be involved in OP. | ||
| 650 | 4 | |a Organizing pneumonia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Cryptogenic organizing pneumonia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Occupational exposure |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Environmental exposure |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Chaigne, Benjamin |e verfasserin |4 aut | |
| 700 | 1 | |a Marchand-Adam, Sylvain |e verfasserin |4 aut | |
| 700 | 1 | |a Lasfargues, Gérard |e verfasserin |4 aut | |
| 700 | 1 | |a Diot, Elisabeth |e verfasserin |4 aut | |
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