Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers
Rationale Sex differences in the analgesic effects of mu-opioid agonists have been documented extensively in rodents and, to a lesser extent, in non-human primates. To date, there have been few experimental studies investigating this effect in humans, and the conclusions have been equivocal. Objectives The aims of the present study were to examine potential sex differences in the analgesic, subjective, performance, and physiological effects of morphine in human research volunteers. Methods Using a double-blind outpatient procedure, the present study investigated the effects of intramuscular morphine (0, 5, and 10 mg/70 kg, i.m.) in men (N = 8) and women (N = 10). The primary dependent measure was analgesia, as assessed by the cold pressor and mechanical pressure tests. Secondary dependent measures included subjective, performance, and physiological effects of morphine, as well as plasma levels of morphine. Results No differences in the analgesic and performance effects of morphine were observed between men and women, but significant differences in morphine’s subjective effects were found. Specifically, men reported greater positive effects, whereas women reported greater negative effects after morphine administration. Conclusions These data suggest that, in humans, there are sex differences in the subjective mood-altering effects of morphine but, based on this limited sample, there is little evidence for sex differences in its analgesic effects..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
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| Enthalten in: |
Psychopharmacology - 208(2009), 1 vom: 27. Okt. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Comer, Sandra D. [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
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| Anmerkungen: |
© Springer-Verlag 2009 |
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| doi: |
10.1007/s00213-009-1703-4 |
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| funding: |
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SPR002013150 |
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| 245 | 1 | 0 | |a Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers |
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| 520 | |a Rationale Sex differences in the analgesic effects of mu-opioid agonists have been documented extensively in rodents and, to a lesser extent, in non-human primates. To date, there have been few experimental studies investigating this effect in humans, and the conclusions have been equivocal. Objectives The aims of the present study were to examine potential sex differences in the analgesic, subjective, performance, and physiological effects of morphine in human research volunteers. Methods Using a double-blind outpatient procedure, the present study investigated the effects of intramuscular morphine (0, 5, and 10 mg/70 kg, i.m.) in men (N = 8) and women (N = 10). The primary dependent measure was analgesia, as assessed by the cold pressor and mechanical pressure tests. Secondary dependent measures included subjective, performance, and physiological effects of morphine, as well as plasma levels of morphine. Results No differences in the analgesic and performance effects of morphine were observed between men and women, but significant differences in morphine’s subjective effects were found. Specifically, men reported greater positive effects, whereas women reported greater negative effects after morphine administration. Conclusions These data suggest that, in humans, there are sex differences in the subjective mood-altering effects of morphine but, based on this limited sample, there is little evidence for sex differences in its analgesic effects. | ||
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| 650 | 4 | |a Subjective effects |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Opioids |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Humans |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Cooper, Ziva D. |4 aut | |
| 700 | 1 | |a Kowalczyk, William J. |4 aut | |
| 700 | 1 | |a Sullivan, Maria A. |4 aut | |
| 700 | 1 | |a Evans, Suzette M. |4 aut | |
| 700 | 1 | |a Bisaga, Adam M. |4 aut | |
| 700 | 1 | |a Vosburg, Suzanne K. |4 aut | |
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