About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants

Abstract It is unknown whether the well-known association between vitamin D deficiency and mortality could be explained by the immune system modulating effects of vitamin D, which may protect from a systemic inflammatory response (SIR) to adverse health conditions. This study aims to investigate the interrelationships of vitamin D deficiency, biomarkers of SIR, and mortality. We used multivariate logistic regression with adjustment for 51 covariates to assess the associations of vitamin D deficiency with disadvantageous levels of nine biomarkers of SIR in the UK Biobank cohort. Furthermore, we tested with Cox regression and mediation analysis whether biomarkers of SIR and vitamin D deficiency were independently associated with mortality. We included 397,737 participants aged 37–73 years. Vitamin D deficiency was associated with disadvantageous levels of all blood cell count-based biomarkers, but not with C-reactive protein (CRP)-based biomarkers after adjustment for body weight. Vitamin D deficiency and all biomarkers of SIR were significantly associated with all-cause mortality and mortality from cancer, cardiovascular and respiratory disease. The strength of these associations was unaltered if vitamin D deficiency and biomarkers of SIR were put in the same model. This finding was further supported by the mediation analyses. This study showed that vitamin D deficiency is associated with disadvantageous levels of blood cell count-based but not CRP-based biomarkers of SIR. Vitamin D deficiency and systemic inflammation were independently and strongly associated with mortality. The potential of clinical interventions against both vitamin D deficiency and underlying causes of systemic inflammation should be explored..

Medienart:	Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:38
Enthalten in:	European journal of epidemiology - 38(2023), 9 vom: 21. Juni, Seite 957-971

Sprache:	Englisch

Beteiligte Personen:	Sha, Sha [VerfasserIn] Gwenzi, Tafirenyika [VerfasserIn] Chen, Li-Ju [VerfasserIn] Brenner, Hermann [VerfasserIn] Schöttker, Ben [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	All-cause mortality Cancer mortality Cardiovascular mortality Systemic inflammatory response Vitamin D

Anmerkungen:	© The Author(s) 2023

doi:	10.1007/s10654-023-01023-2

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2145549536