Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence?
Introduction Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or eyes, in the absence of systemic diffusion. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a newly identified benign immune-mediated CNS inflammatory disorder with specific anti-MOG antibody seropositivity. These two seemingly unrelated nosological entities both have abundant clinical and radiological manifestations, and whether there is a potential link between them is unclear. Case report We describe a 49-year-old man who presented progressive headache, dizziness, and unsteady gait with multifocal scattered T2 hyperintensities with contrast enhancement. The serum anti-MOG antibody test was positive, and a brain biopsy showed inflammatory infiltration. Initially, he was diagnosed with MOGAD and his condition improved after corticosteroid therapy. The patient relapsed with exacerbation of symptoms and neuroimaging showed new mass-forming lesions four months later. A second brain biopsy confirmed PCNSL. Discussion This is the first report of histologically confirmed successive MOGAD and PCNSL. Our case broadens the phenotypic spectrum of sentinel lesions in PCNSL. Though rare, PCNSL should be considered in patients diagnosed with benign CNS inflammatory disorder and responding well to steroid treatment when their clinical symptoms worsen and the imaging deteriorates. A timely biopsy is critical for accurate diagnosis and appropriate therapy..
Medienart: |
Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
---|---|
Enthalten in: |
Neurological sciences - 44(2023), 10 vom: 30. Juni, Seite 3711-3715 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Cai, Meng-Ting [VerfasserIn] |
---|
Links: |
Volltext [lizenzpflichtig] |
---|
BKL: | |
---|---|
Themen: |
Biopsy |
Anmerkungen: |
© Fondazione Società Italiana di Neurologia 2023 |
---|
doi: |
10.1007/s10072-023-06919-1 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
OLC214549457X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | OLC214549457X | ||
003 | DE-627 | ||
005 | 20240118104956.0 | ||
007 | tu | ||
008 | 240118s2023 xx ||||| 00| ||eng c | ||
024 | 7 | |a 10.1007/s10072-023-06919-1 |2 doi | |
035 | |a (DE-627)OLC214549457X | ||
035 | |a (DE-He213)s10072-023-06919-1-p | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q VZ |
084 | |a 44.90$jNeurologie |2 bkl | ||
100 | 1 | |a Cai, Meng-Ting |e verfasserin |4 aut | |
245 | 1 | 0 | |a Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence? |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a © Fondazione Società Italiana di Neurologia 2023 | ||
520 | |a Introduction Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or eyes, in the absence of systemic diffusion. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a newly identified benign immune-mediated CNS inflammatory disorder with specific anti-MOG antibody seropositivity. These two seemingly unrelated nosological entities both have abundant clinical and radiological manifestations, and whether there is a potential link between them is unclear. Case report We describe a 49-year-old man who presented progressive headache, dizziness, and unsteady gait with multifocal scattered T2 hyperintensities with contrast enhancement. The serum anti-MOG antibody test was positive, and a brain biopsy showed inflammatory infiltration. Initially, he was diagnosed with MOGAD and his condition improved after corticosteroid therapy. The patient relapsed with exacerbation of symptoms and neuroimaging showed new mass-forming lesions four months later. A second brain biopsy confirmed PCNSL. Discussion This is the first report of histologically confirmed successive MOGAD and PCNSL. Our case broadens the phenotypic spectrum of sentinel lesions in PCNSL. Though rare, PCNSL should be considered in patients diagnosed with benign CNS inflammatory disorder and responding well to steroid treatment when their clinical symptoms worsen and the imaging deteriorates. A timely biopsy is critical for accurate diagnosis and appropriate therapy. | ||
650 | 4 | |a Myelin oligodendrocyte glycoprotein antibody-associated disease | |
650 | 4 | |a Primary central nervous system lymphoma | |
650 | 4 | |a Sentinel lesions | |
650 | 4 | |a Biopsy | |
700 | 1 | |a Lai, Qi-Lun |4 aut | |
700 | 1 | |a Tang, Jin-Long |4 aut | |
700 | 1 | |a Du, Bing-Qing |4 aut | |
700 | 1 | |a Shen, Chun-Hong |4 aut | |
700 | 1 | |a Zhang, Yin-Xi |0 (orcid)0000-0002-1595-235X |4 aut | |
700 | 1 | |a Guo, Yi |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Neurological sciences |d Springer International Publishing, 1999 |g 44(2023), 10 vom: 30. Juni, Seite 3711-3715 |w (DE-627)320571521 |w (DE-600)2016546-8 |x 1590-1874 |7 nnns |
773 | 1 | 8 | |g volume:44 |g year:2023 |g number:10 |g day:30 |g month:06 |g pages:3711-3715 |
856 | 4 | 1 | |u https://doi.org/10.1007/s10072-023-06919-1 |z lizenzpflichtig |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a SYSFLAG_A | ||
912 | |a GBV_OLC | ||
912 | |a SSG-OLC-PSY | ||
936 | b | k | |a 44.90$jNeurologie |q VZ |0 106409980 |0 (DE-625)106409980 |
951 | |a AR | ||
952 | |d 44 |j 2023 |e 10 |b 30 |c 06 |h 3711-3715 |