Neurophysiological correlates of altered time awareness in Alzheimer’s disease and frontotemporal dementia

Background Alterations in time awareness have been reported in dementia, particularly in Alzheimer's disease (AD) and frontotemporal dementia (FTD). However, the neurophysiological correlates underlying these alterations remain largely unexplored. This study aimed to investigate the neurophysiological correlates of altered time awareness in AD and FTD patients. Methods A total of 150 participants (50 AD patients, 50 FTD patients, and 50 healthy controls [HC]) underwent a standardized neuropsychological assessment, an altered time awareness survey, and transcranial magnetic stimulation (TMS) to assess cholinergic (short latency afferent inhibition—SAI), GABAergic (short interval intracortical inhibition—SICI), and glutamatergic (intracortical facilitation—ICF) circuits. Results In AD patients, the most frequent symptom was difficulty in ordering past events (52.0%), while FTD patients primarily struggled with estimating temporal intervals between events (40.0%). Significant differences were observed between HC and both patient groups, as well as between AD and FTD patients in their tendency to re-live past events. Binomial logistic regression analysis revealed that impairments in glutamatergic and cholinergic circuits significantly predicted the likelihood of participants manifesting altered time awareness symptoms. Conclusions This study provides novel insights into the neurophysiological correlates of altered time awareness in AD and FTD patients, highlighting the involvement of specific neurotransmitter circuits, particularly glutamatergic and cholinergic circuits. Further research is needed to explore the potential clinical implications and therapeutic targets arising from these findings..

Medienart:

E-Artikel

Erscheinungsjahr:

2023

Erschienen:

2023

Enthalten in:

Zur Gesamtaufnahme - volume:44

Enthalten in:

Neurological sciences - 44(2023), 10 vom: 29. Mai, Seite 3515-3522

Sprache:

Englisch

Beteiligte Personen:

Bracca, Valeria [VerfasserIn]
Cantoni, Valentina [VerfasserIn]
Gadola, Yasmine [VerfasserIn]
Rivolta, Jasmine [VerfasserIn]
Cosseddu, Maura [VerfasserIn]
Turrone, Rosanna [VerfasserIn]
Caratozzolo, Salvatore [VerfasserIn]
Di Luca, Monica [VerfasserIn]
Padovani, Alessandro [VerfasserIn]
Borroni, Barbara [VerfasserIn]
Benussi, Alberto [VerfasserIn]

Links:

Volltext [lizenzpflichtig]

BKL:

44.90$jNeurologie

Themen:

Acetylcholine
Alzheimer’s disease
Frontotemporal dementia
GABA
Glutamate
Time-awareness
Transcranial magnetic stimulation

Anmerkungen:

© Fondazione Società Italiana di Neurologia 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:

10.1007/s10072-023-06877-8

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

OLC2145494324

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