Details der Publikation - Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase

Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase

Abstract The Dengue Virus (DENV) non-structural protein 3 (NS3) is a multi-functional protein critical in the viral life cycle. The DENV NS3 is comprised of a serine protease domain and a helicase domain. The helicase domain itself acts as a molecular motor, either translocating in a unidirectional manner along single-stranded RNA or unwinding double-stranded RNA, processes fueled by the hydrolysis of nucleoside triphosphates. In this brief review, we summarize our contributions and ongoing efforts to uncover the thermodynamic and mechanistic functional properties of the DENV NS3 as an NTPase and helicase..

Medienart:	E-Artikel

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	Zur Gesamtaufnahme - volume:15
Enthalten in:	Biophysical reviews - 15(2023), 4 vom: Aug., Seite 591-600

Sprache:	Englisch

Beteiligte Personen:	Incicco, J. Jeremías [VerfasserIn] Cababie, Leila A. [VerfasserIn] Sarto, Carolina [VerfasserIn] Adler, Natalia S. [VerfasserIn] Amrein, Fernando [VerfasserIn] Mikkelsen, Evelyn [VerfasserIn] Arrar, Mehrnoosh [VerfasserIn] Kaufman, Sergio B. [VerfasserIn]

Links:	Volltext [lizenzpflichtig]

Themen:	Dengue Helicase Molecular motors NS3

Anmerkungen:	© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

doi:	10.1007/s12551-023-01101-5

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	OLC2145420711

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520			\|a Abstract The Dengue Virus (DENV) non-structural protein 3 (NS3) is a multi-functional protein critical in the viral life cycle. The DENV NS3 is comprised of a serine protease domain and a helicase domain. The helicase domain itself acts as a molecular motor, either translocating in a unidirectional manner along single-stranded RNA or unwinding double-stranded RNA, processes fueled by the hydrolysis of nucleoside triphosphates. In this brief review, we summarize our contributions and ongoing efforts to uncover the thermodynamic and mechanistic functional properties of the DENV NS3 as an NTPase and helicase.
650		4	\|a NS3
650		4	\|a Helicase
650		4	\|a Molecular motors
650		4	\|a Dengue
700	1		\|a Cababie, Leila A. \|4 aut
700	1		\|a Sarto, Carolina \|4 aut
700	1		\|a Adler, Natalia S. \|4 aut
700	1		\|a Amrein, Fernando \|4 aut
700	1		\|a Mikkelsen, Evelyn \|4 aut
700	1		\|a Arrar, Mehrnoosh \|0 (orcid)0000-0001-6404-0552 \|4 aut
700	1		\|a Kaufman, Sergio B. \|4 aut
773	0	8	\|i Enthalten in \|t Biophysical reviews \|d Springer Berlin Heidelberg, 2009 \|g 15(2023), 4 vom: Aug., Seite 591-600 \|h Online-Ressource \|w (DE-627)594778719 \|w (DE-600)2486483-3 \|w (DE-576)307016269 \|x 1867-2469 \|7 nnns
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Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase

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