Chemical Composition and Biological Activities of Essential Oil from Kaempferia rotunda
Abstract Kaempferia rotunda Linn. belongs to family Zingiberaceae has been traditionally used to cure several diseases and has been used as folk medicines because of having tremendous therapeutic potential. In the current study, the chemical constituents of the essential oil obtained from the fresh rhizome of K. rotunda by hydrodistillation method were analyzed by Gas Chromatography-Mass Spectrometry (GC–MS). Nine constituents have been identified in the essential oil of K. rotunda accounting for 96.79% of the total peak area. The major compounds were benzoic acid (58.25 ± 0.14%) followed by bornyl acetate (14.4 ± 0.35%), zingiberene (5.75 ± 0.08%) and β-myrcene (3.87 ± 0.08%), etc. Further, antioxidant, antimicrobial and cytotoxic activities of the essential oil were assessed. Antioxidant activity of the oil was determined by scavenging DPPH radical in terms of their 50% inhibition ($ IC_{50} $) values. Oil exhibited moderate to strong antioxidant activity. Antimicrobial activity was evaluated using Inhibition Zone Diameter (IZD) and Minimum Inhibitory Concentration (MIC) values, whereas cytotoxic activity was studied using MCF7 and HeLa human cancer cell lines. K. rotunda oil exhibited stronger antimicrobial activity against the gram-negative bacteria than the rest pathogens. Rhizome oil of K. rotunda exhibited 75.63% ± 5.66 percentage of cell inhibition for HeLa and 68.44% ± 2.51 for MCF7 cell line at 20 μg/ml concentration. Hence, it is concluded that K. rotunda rhizome essential oil can be considered as natural antioxidant and antimicrobial agent, and it can be used in food and pharmaceutical industries..
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:93 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences / A - 93(2023), 3 vom: 27. Apr., Seite 669-675 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sahoo, Suprava [VerfasserIn] |
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| Links: |
Volltext [lizenzpflichtig] |
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| Themen: |
Antimicrobial activity |
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| Anmerkungen: |
© The Author(s), under exclusive licence to The National Academy of Sciences, India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| doi: |
10.1007/s40011-023-01458-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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OLC2145319387 |
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| 520 | |a Abstract Kaempferia rotunda Linn. belongs to family Zingiberaceae has been traditionally used to cure several diseases and has been used as folk medicines because of having tremendous therapeutic potential. In the current study, the chemical constituents of the essential oil obtained from the fresh rhizome of K. rotunda by hydrodistillation method were analyzed by Gas Chromatography-Mass Spectrometry (GC–MS). Nine constituents have been identified in the essential oil of K. rotunda accounting for 96.79% of the total peak area. The major compounds were benzoic acid (58.25 ± 0.14%) followed by bornyl acetate (14.4 ± 0.35%), zingiberene (5.75 ± 0.08%) and β-myrcene (3.87 ± 0.08%), etc. Further, antioxidant, antimicrobial and cytotoxic activities of the essential oil were assessed. Antioxidant activity of the oil was determined by scavenging DPPH radical in terms of their 50% inhibition ($ IC_{50} $) values. Oil exhibited moderate to strong antioxidant activity. Antimicrobial activity was evaluated using Inhibition Zone Diameter (IZD) and Minimum Inhibitory Concentration (MIC) values, whereas cytotoxic activity was studied using MCF7 and HeLa human cancer cell lines. K. rotunda oil exhibited stronger antimicrobial activity against the gram-negative bacteria than the rest pathogens. Rhizome oil of K. rotunda exhibited 75.63% ± 5.66 percentage of cell inhibition for HeLa and 68.44% ± 2.51 for MCF7 cell line at 20 μg/ml concentration. Hence, it is concluded that K. rotunda rhizome essential oil can be considered as natural antioxidant and antimicrobial agent, and it can be used in food and pharmaceutical industries. | ||
| 650 | 4 | |a Essential oil | |
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| 650 | 4 | |a Antioxidant activity | |
| 650 | 4 | |a Antimicrobial activity | |
| 650 | 4 | |a Cytotoxic activity | |
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